N-Acetilaspartinska kiselina
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| N-Acetilaspartinska kiselina | |||
|---|---|---|---|
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| IUPAC ime |
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| Identifikacija | |||
| CAS registarski broj | 2545-40-6  , 997-55-7 S
| ||
| PubChem[2][3] | 97508, 774916 R, 65065 S | ||
| ChemSpider[4] | 88007 , 677387 R
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| EINECS broj | |||
| KEGG[5] | |||
| MeSH | |||
| ChEBI | 21547 | ||
| ChEMBL[6] | CHEMBL1162493
| ||
| RTECS registarski broj toksičnosti | CI9098600 | ||
| Bajlštajn | 1726198 S | ||
| 3DMet | B00227 | ||
| Jmol-3D slike | Slika 1 Slika 2 | ||
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| Svojstva | |||
| Molekulska formula | C6H9NO5 | ||
| Molarna masa | 175.14 g mol−1 | ||
| Agregatno stanje | Bezbojni, transparentni kristali | ||
| Tačka ključanja |
141-144 °C, 414-417 K, 286-291 °F | ||
| log P | −2.209 | ||
| pKa | 3.142 | ||
| Baznost (pKb) | 10.855 | ||
| Opasnost | |||
| S-oznake | S22, S24/25 | ||
| Srodna jedinjenja | |||
| Srodna alkanoinske kiseline | |||
| Srodna jedinjenja | |||
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Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala | |||
| Infobox references | |||
N-Acetilaspartic acid (N-acetilaspartat, NAA) je derivat aspartinske kiseline sa formulom C6H9NO5 i molekulskom težinom 175,139.
NAA je drugi po zastupljenosti neurotransmiter u mozgu, posle glutamatne aminokiseline. On je prisutan u mozgu odraslih osoba jedino u neuronima.[7] Sintetiše se u mitochondrijama[8] iz aspartinske kiseline i acetil-koenzimA A.
Reference[uredi | uredi kod]
- ↑ „N-acetylaspartate - Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005.. Identification. Pristupljeno 8. 1. 2012.
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Simmons, Frondoza et al. 1991 PMID 1754068; Moffett, Namboodiri et al. 1991
- ↑ Patel, T. B. and J. B. Clark (1979). "Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport." Biochem J 184(3): 539-46.
Literatura[uredi | uredi kod]
- N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System, eds., J.R.Moffett, S.B.Tieman, D.R.Weinberger, J.T.Coyle, and M.A.Namboodiri, pp. 7–26. New York, NY: Springer Science + Business Media, 2006.
- Biochemical Support for the "Threshold" Theory of Creativity: A Magnetic Resonance Spectroscopy Study, Rex E. Jung et al., April 22, 2009, 29(16):5319-5325; DOI:10.1523/JNEUROSCI.0588-09.2009
