N-Acetilaspartinska kiselina

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N-Acetilaspartinska kiselina
Stereo, skeletal formula of N-acetylaspartic acid (S)
IUPAC ime
Identifikacija
CAS registarski broj 2545-40-6 YesY, 997-55-7 S YesY
PubChem[2][3] 97508
774916 R
65065 S
ChemSpider[4] 88007 YesY, 677387 R YesY
EINECS broj 219-827-5
KEGG[5] C01042
MeSH N-acetylaspartate
ChEBI 21547
ChEMBL[6] CHEMBL1162493 YesY
RTECS registarski broj toksičnosti CI9098600
Bajlštajn 1726198 S
3DMet B00227
Jmol-3D slike Slika 1
Slika 2
Svojstva
Molekulska formula C6H9NO5
Molarna masa 175.14 g mol−1
Agregatno stanje Bezbojni, transparentni kristali
Tačka ključanja

141-144 °C, 414-417 K, 286-291 °F

log P −2.209
pKa 3.142
Baznost (pKb) 10.855
Opasnost
S-oznake S22, S24/25
Srodna jedinjenja
Srodna alkanoinske kiseline
Srodna jedinjenja

 YesY (šta je ovo?)   (verifikuj)

Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

N-Acetilaspartic acid (N-acetilaspartat, NAA) je derivat aspartinske kiseline sa formulom C6H9NO5 i molekulskom težinom 175,139.

NAA je drugi po zastupljenosti neurotransmiter u mozgu, posle glutamatne aminokiseline. On je prisutan u mozgu odraslih osoba jedino u neuronima.[7] Sintetiše se u mitochondrijama[8] iz aspartinske kiseline i acetil-koenzimA A.

Reference[uredi - уреди]

  1. "N-acetylaspartate - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 26. 3. 2005.. Identification. http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=97508. pristupljeno 8. 1. 2012.. 
  2. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  3. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  4. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). "Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining". J Cheminform 2 (1): 3. doi:10.1186/1758-2946-2-3. PMID 20331846.  edit
  5. Joanne Wixon, Douglas Kell (2000). "Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG". Yeast 17 (1): 48–55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  6. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). "ChEMBL: a large-scale bioactivity database for drug discovery". Nucleic Acids Res 40 (Database issue): D1100–7. doi:10.1093/nar/gkr777. PMID 21948594.  edit
  7. Simmons, Frondoza et al. 1991 PMID 1754068; Moffett, Namboodiri et al. 1991
  8. Patel, T. B. and J. B. Clark (1979). "Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport." Biochem J 184(3): 539-46.

Literatura[uredi - уреди]

  • N-Acetylaspartate: A Unique Neuronal Molecule in the Central Nervous System, eds., J.R.Moffett, S.B.Tieman, D.R.Weinberger, J.T.Coyle, and M.A.Namboodiri, pp. 7–26. New York, NY: Springer Science + Business Media, 2006.
  • Biochemical Support for the "Threshold" Theory of Creativity: A Magnetic Resonance Spectroscopy Study, Rex E. Jung et al., April 22, 2009, 29(16):5319-5325; DOI:10.1523/JNEUROSCI.0588-09.2009

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