Mikrozomalna epoksidna hidrolaza

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Mikrozomalna epoksidna hidrolaza
Identifikatori
EC broj 3.3.2.9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Mikrozomalna epoksidna hidrolaza (EC 3.3.2.9, epoksidna hidrataza, mikrozomalno epoksidna hidrataza, epoksidna hidraza, mikrozomalno epoksidna hidraza, aren-oksidna hidrataza, benzo(a)piren-4,5-oksidna hidrataza, benzo(a)piren-4,5-epoksidna hidrataza, aril epoksidna hidraza, cis-epoksidna hidrolaza, mEH) je enzim sa sistematskim imenom cis-stilben-oksidna hidrolaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju

cis-stilben oksid + H2O \rightleftharpoons (+)-(1R,2R)-1,2-difeniletan-1,2-diol

Ovaj ključni hepatički enzim učestvuje u metabolizmu brojnih ksenobiotika, poput 1,3-butadien oksida, stiren oksida i policikličnnog aromatičnog ugljovodonika benzo[a]piren 4,5-oksida.

Reference[uredi - уреди]

  1. Jakoby, W.B. and Fjellstedt, T.A. (1972). "Epoxidases". u: Boyer, P.D.. The Enzymes. 7 (3rd izd.). New York: Academic Press. str. 199-212. 
  2. Lu, A.Y., Ryan, D., Jerina, D.M., Daly, J.W. and Levin, W. (1975). "Liver microsomal expoxide hydrase. Solubilization, purification, and characterization". J. Biol. Chem. 250: 8283–8288. PMID 240858. 
  3. Oesch, F. (1974). "Purification and specificity of a human microsomal epoxide hydratase". Biochem. J. 139: 77–88. PMID 4463951. 
  4. Oesch, F. and Daly, J. (1971). "Solubilization, purification, and properties of a hepatic epoxide hydrase". Biochim. Biophys. Acta 227: 692–697. PMID 4998715. 
  5. Bellucci, G., Chiappe, C. and Ingrosso, G. (1994). "Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides". Chirality 6: 577–582. PMID 7986671. 
  6. Morisseau, C. and Hammock, B.D. (2005). "Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles". Annu. Rev. Pharmacol. Toxicol. 45: 311–333. PMID 15822179. 
  7. Fretland, A.J. and Omiecinski, C.J. (2000). "Epoxide hydrolases: biochemistry and molecular biology". Chem. Biol. Interact. 129: 41–59. PMID 11154734. 
  8. Oesch, F. (1973). "Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds". Xenobiotica 3: 305–340. PMID 4584115. 
  9. Lacourciere, G.M. and Armstrong, R.N. (1994). "Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes". Chem. Res. Toxicol. 7: 121–124. PMID 8199297. 
  10. Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). "Epoxide hydrolases: their roles and interactions with lipid metabolism". Prog. Lipid Res. 44: 1–51. PMID 15748653. 

Literatura[uredi - уреди]

  • Jakoby, W.B. and Fjellstedt, T.A. (1972). "Epoxidases". u: Boyer, P.D.. The Enzymes. 7 (3rd izd.). New York: Academic Press. str. 199-212. 

Spoljašnje veze[uredi - уреди]