Mikrozomalna epoksidna hidrolaza
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| Mikrozomalna epoksidna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.3.2.9 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Mikrozomalna epoksidna hidrolaza (EC 3.3.2.9, epoksidna hidrataza, mikrozomalno epoksidna hidrataza, epoksidna hidraza, mikrozomalno epoksidna hidraza, aren-oksidna hidrataza, benzo(a)piren-4,5-oksidna hidrataza, benzo(a)piren-4,5-epoksidna hidrataza, aril epoksidna hidraza, cis-epoksidna hidrolaza, mEH) je enzim sa sistematskim imenom cis-stilben-oksidna hidrolaza.[1][2][3][4][5][6][7][8][9][10] Ovaj enzim katalizuje sledeću hemijsku reakciju
- cis-stilben oksid + H2O (+)-(1R,2R)-1,2-difeniletan-1,2-diol
Ovaj ključni hepatički enzim učestvuje u metabolizmu brojnih ksenobiotika, poput 1,3-butadien oksida, stiren oksida i policikličnnog aromatičnog ugljovodonika benzo[a]piren 4,5-oksida.
Reference[uredi | uredi kod]
- ↑ Jakoby, W.B. and Fjellstedt, T.A. (1972). „Epoxidases”. u: Boyer, P.D.. The Enzymes. 7 (3rd izd.). New York: Academic Press. str. 199-212.
- ↑ Lu, A.Y., Ryan, D., Jerina, D.M., Daly, J.W. and Levin, W. (1975). „Liver microsomal expoxide hydrase. Solubilization, purification, and characterization”. J. Biol. Chem. 250: 8283-8288. PMID 240858.
- ↑ Oesch, F. (1974). „Purification and specificity of a human microsomal epoxide hydratase”. Biochem. J. 139: 77-88. PMID 4463951.
- ↑ Oesch, F. and Daly, J. (1971). „Solubilization, purification, and properties of a hepatic epoxide hydrase”. Biochim. Biophys. Acta 227: 692-697. PMID 4998715.
- ↑ Bellucci, G., Chiappe, C. and Ingrosso, G. (1994). „Kinetics and stereochemistry of the microsomal epoxide hydrolase-catalyzed hydrolysis of cis-stilbene oxides”. Chirality 6: 577-582. PMID 7986671.
- ↑ Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles”. Annu. Rev. Pharmacol. Toxicol. 45: 311-333. PMID 15822179.
- ↑ Fretland, A.J. and Omiecinski, C.J. (2000). „Epoxide hydrolases: biochemistry and molecular biology”. Chem. Biol. Interact. 129: 41-59. PMID 11154734.
- ↑ Oesch, F. (1973). „Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds”. Xenobiotica 3: 305-340. PMID 4584115.
- ↑ Lacourciere, G.M. and Armstrong, R.N. (1994). „Microsomal and soluble epoxide hydrolases are members of the same family of C-X bond hydrolase enzymes”. Chem. Res. Toxicol. 7: 121-124. PMID 8199297.
- ↑ Newman, J.W., Morisseau, C. and Hammock, B.D. (2005). „Epoxide hydrolases: their roles and interactions with lipid metabolism”. Prog. Lipid Res. 44: 1-51. PMID 15748653.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Jakoby, W.B. and Fjellstedt, T.A. (1972). „Epoxidases”. u: Boyer, P.D.. The Enzymes. 7 (3rd izd.). New York: Academic Press. str. 199-212.