Metionin-tRNK ligaza
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| Metionin-tRNK ligaza | |||||||||
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| Metionin-tRNK ligaza monomer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 6.1.1.10 | ||||||||
| CAS broj | 9033-22-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Metionin-tRNK ligaza (EC 6.1.1.10, metionil-tRNK sintetaza, metionil-transferna ribonukleinsko kiselinska sintetaza, metionil-transferna ribonukleatna sintetaza, metionil-transferna RNK sintetaza, metioninska translaza, MetRS) je enzim sa sistematskim imenom L-metionin:tRNKMet ligaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
U organizmima koji formiraju N-formilmetionil-tRNKfMet za inicijaciju translacije, ovaj enzim takođe prepoznaje initiator tRNKfMet i katalizuje formiranje L-metionil-tRNKfMet.
Reference[uredi | uredi kod]
- ↑ Bergmann, F.H., Berg, P. and Dieckmann, M. (1961). „The enzymic synthesis of amino acyl derivatives of ribonucleic acid. II. The preparation of leucyl-, valyl-, isoleucyl- and methionyl ribonucleic acid synthetases from Escherichia coli”. J. Biol. Chem. 236: 1735-1740.
- ↑ Lee, C.P., Dyson, M.R., Mandal, N., Varshney, U., Bahramian, B. and RajBhandary, U.L. (1992). „Striking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase”. Proc. Natl. Acad. Sci. USA 89: 9262-9266. PMID 1409632.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.