Malat dehidrogenaza
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| Malat dehidrogenaza | |||||||||
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| Tetramer malat dehidrogenaze (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.37 | ||||||||
| CAS broj | 9001-64-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Malat dehidrogenaza (EC 1.1.1.37, L-malat dehidrogenaza, NAD-L-malat dehidrogenaza, malatna kiselina dehidrogenaza, NAD-zavisna malitna dehidrogenaza, NAD-malat dehidrogenaza, NAD-malatna dehidrogenaza, malat (NAD) dehidrogenaza, NAD-specifična malat dehidrogenaza, NAD-vezana malat dehidrogenaza, MDH, L-malat-NAD+ oksidoreduktaza) je enzim sa sistematskim imenom (S)-malat:NAD+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (S)-malat + NAD+ oksaloacetat + NADH + H+
Takođe oksiduje nekoliko drugih 2-hidroksidikarboksilnih kiselina.
Reference[uredi | uredi kod]
- ↑ Banaszak, L.J. and Bradshaw, R.A. (1975). „Malate dehydrogenase”. u: Boyer, P.D.. The Enzymes. 11 (3rd izd.). New York: Academic Press. str. 369-396.
- ↑ Guha, A., Englard, S. and Listowsky, I. (1968). „Beef heart malic dehydrogenases. VII. Reactivity of sulfhydryl groups and conformation of the supernatant enzyme”. J. Biol. Chem. 243: 609-615. PMID 5637713.
- ↑ McReynolds, M.S. and Kitto, G.B. (1970). „Purification and properties of Drosophila malate dehydrogenases”. Biochim. Biophys. Acta 198: 165-175. PMID 4313528.
- ↑ Wolfe, R.G. and Nielands, J.B. (1956). „Some molecular and kinetic properties of heart malic dehydrogenase”. J. Biol. Chem. 221: 61-69. PMID 13345798.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.