Ljudski serumski albumin

Izvor: Wikipedia
Ljudski serumski albumin
ALB structure.png
PDB prikaz baziran na 1e7h.
Identifikatori
Simbol ALB
Entrez 213
HUGO 399
OMIM 103600
PDB 1E7H
RefSeq NM_000477
UniProt P02768
Drugi podaci
Lokus Hromozom 4 q13.3

Ljudski serumski albumin je najzastupljeniji protein u ljudskoj krvnoj plazmi. On se formira u jetri. Albumin sačinjava oko polovine krvnog serumskog proteina. On je rastvoran i monomeran. Albuminom se transportuju hormoni, masne kiseline, i druga jedinjenja, puferuje pH, i održava osmotski pritisak, i vrši niz drugih funkcija.[1][2]

Reference[uredi - уреди]

  1. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). "DrugBank 3.0: a comprehensive resource for omics research on drugs". Nucleic Acids Res. 39 (Database issue): D1035-41. DOI:10.1093/nar/gkq1126. PMID 21059682.  edit
  2. Nucleic Acids Res (2008). "DrugBank: a knowledgebase for drugs, drug actions and drug targets". Nucleic acids research 36 (Database issue): D901-6. DOI:10.1093/nar/gkm958. PMID 18048412.  edit

Literatura[uredi - уреди]

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  • Wyatt AR, Wilson MR (2010). "Identification of Human Plasma Proteins as Major Clients for the Extracellular Chaperone Clusterin". J. Biol. Chem. 285 (6): 3532–9. DOI:10.1074/jbc.M109.079566. PMID 19996109. 
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  • Caridi G, Dagnino M, Simundic AM, et al. (2010). "Albumin Benkovac (c.1175 A > G; p.Glu392Gly): a novel genetic variant of human serum albumin". Transl Res 155 (3): 118–9. DOI:10.1016/j.trsl.2009.10.001. PMID 20171595. 
  • Deeb O, Rosales-Hernández MC, Gámez-Castro C, et al. (2010). "Exploration of human serum albumin binding sites by docking and molecular dynamics flexible ligand-protein interactions". Biopolymers 93 (2): 161–70. DOI:10.1002/bip.21314. PMID 19785033. 
  • Karahan SC, Koramaz I, Altun G, et al. (2010). "Ischemia-modified albumin reduction after coronary bypass surgery is associated with the cardioprotective efficacy of cold-blood cardioplegia enriched with N-acetylcysteine: a preliminary study". Eur Surg Res 44 (1): 30–6. DOI:10.1159/000262324. PMID 19955769. 
  • Jin C, Lu L, Zhang RY, et al. (2009). "Association of serum glycated albumin, C-reactive protein and ICAM-1 levels with diffuse coronary artery disease in patients with type 2 diabetes mellitus". Clin. Chim. Acta 408 (1–2): 45–9. DOI:10.1016/j.cca.2009.07.003. PMID 19615354. 

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