Lizostafin
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| Lizostafin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 3.4.24.75 | ||||||||
| CAS broj | 9011-93-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Lizostafin (EC 3.4.24.75, glicil-glicinska endopeptidaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza -Gly-Gly- veza u pentaglicinskoj interpeptidnoj vezi kojom se povezuje stafilokokalni ćelijski zid peptidoglikana
Ova cink-zavisna endopeptidaza je prisutna u Staphylococcus simulans.
Reference[uredi | uredi kod]
- ↑ Recsei, P.A., Gruss, A.D. and Novick, R.P. (1987). „Cloning, sequence, and expression of the lysostaphin gene from Staphylococcus simulans”. Proc. Natl. Acad. Sci. USA 84: 1127-1131. PMID 3547405.
- ↑ Baba, T. and Schneewind, O. (1996). „Target cell specificity of a bacteriocin molecule: A C-terminal signal directs lysostaphin to the cell wall of Staphylococcus aureus'”. EMBO J. 15: 4789-4797. PMID 8890152.
- ↑ Thumm, G. and Götz, F. (1997). „Studies on prolysostaphin processing and characterization of the lysostaphin immunity factor (Lif) of Staphylococcus simulans biovar staphylolyticus”. Mol. Microbiol. 23: 1251-1265. PMID 9106216.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.