Lizofosfatidilholin

Izvor: Wikipedia
Generalna hemijska struktura lizofosfatidilholina, gde je R varijabilni lanac masne kiseline

Lizofosfatidilholini (LPC), ili lizolecitini, su klasa hemijskih jedinjenja koja su izvedena iz fosfatidilholina.[1] Oni proizilaze iz parcijalne hidrolize fosfatidilholina, koja uklanja jednu od grupa masnih kiselina. Hidroliza je generalno rezultat enzimskog dejstva fosfolipaze A2.[2][3][4]

LPC se može koristiti u laboratoriji za izazivanje demijelinacije režnjeva mozga, čime se oponašaju efekti demijelinacionih oboljenja kao što je multipla skleroza..[1][5]

Vidi još[uredi - уреди]

Reference[uredi - уреди]

  1. 1.0 1.1 Horrocks, Lloyd A.; Farooqui, Akhlaq A. (2007). Glycerophospholipids in the brain phospholipases A2 in neurological disorders. Berlin: Springer. ISBN 0-387-36602-4. 
  2. "Phosphatidylcholine and related lipids, lipidlibrary.co.uk". http://www.lipidlibrary.co.uk/Lipids/pc/index.htm. 
  3. Robinson BS, Yao ZM, Baisted DJ, Vance DE (May 1989). "Lysophosphatidylcholine metabolism and lipoprotein secretion by cultured rat hepatocytes deficient in choline". The Biochemical Journal 260 (1): 207–14. PMC 1138647. PMID 2775183. Retrieved 10. 4. 2011.. 
  4. Illingworth DR, Portman OW (November 1972). "The uptake and metabolism of plasma lysophosphatidylcholine in vivo by the brain of squirrel monkeys". The Biochemical Journal 130 (2): 557–67. PMC 1174436. PMID 4198083. Retrieved 10. 4. 2011.. 
  5. Degaonkar MN, Raghunathan P, Jayasundar R, Jagannathan NR (January 2005). "Determination of relaxation characteristics during preacute stage of lysophosphatidyl choline-induced demyelinating lesion in rat brain: an animal model of multiple sclerosis". Magnetic Resonance Imaging 23 (1): 69–73. doi:10.1016/j.mri.2004.11.010. PMID 15733790. Retrieved 10. 4. 2011.. 

Literatura[uredi - уреди]

  • Horrocks, Lloyd A.; Farooqui, Akhlaq A. (2007). Glycerophospholipids in the brain phospholipases A2 in neurological disorders. Berlin: Springer.