Leukolizin
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| Leukolizin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.6 | ||||||||
| CAS broj | 72561-03-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Leukolizin (EC 3.4.24.6, leuostomna neutralna proteinaza, leuostomna peptidaza A) je enzim.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Phe1-Val, His5-Leu, Ala14-Leu, Gly20-Glu, Gly23-Phe i Phe24-Phe veza u lancima insulina B kao i u N-blokiranim dipeptidima
Ovaj enzim je prisutan u venumu zmije Agkistrodon piscivorus leuostoma.
Reference[uredi | uredi kod]
- ↑ Wagner, F.W., Spiekerman, A.M. and Prescott, J.M. (1968). „Leucostoma peptidase A. Isolation and physical properties”. J. Biol. Chem. 243: 4486-4493. PMID 5684005.
- ↑ Spiekerman, A.M., Fredericks, K.K., Wagner, F.W. and Prescott, J.M. (1973). „Leucostoma peptidase A: a metalloprotease from snake venom”. Biochim. Biophys. Acta 293: 464-475. PMID 4711816.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.