Leukocitna elastaza

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Leukocitna elastaza
Protein ELA2 PDB 1b0f.png
Identifikatori
EC broj 3.4.21.37
CAS broj 2594837
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Leukocitna elastaza (EC 3.4.21.37, lizozomalna elastaza, neutrofilna elastaza, polimorfonuklearna leukocitna elastaza, elastaza, elaszim, serinska elastaza, lizozomalna elastaza, granulocitna elastaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina, uključujući elastin. Preferentno odvajanje Val- > Ala-

Ovaj enzim se razlikuje od pankreasne elastaze po specifičnosti na sintetičim supstratima i po senzitivnosti na inhibitore.

Reference[uredi - уреди]

  1. Barrett, A.J. (1981). "Leukocyte elastase". Methods Enzymol. 80: 581–588. PMID 7043201. 
  2. Harper, J.W., Cook, R.R., Roberts, C.J., McLaughlin, B.J. and Powers, J.C. (1984). "Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin Aα, and Staphylococcus aureus' protease V-8 using tripeptide thiobenzyl ester substrates". Biochemistry 23: 2995–3002. PMID 6380580. 
  3. Stein, R.L., Strimpler, A.M., Hori, H. and Powers, J.C. (1987). "Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements". Biochemistry 26: 1301–1305. PMID 3646070. 
  4. Bode, W., Meyer, E., Jr. and Powers, J.C. (1989). "Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors". Biochemistry 28: 1951–1963. PMID 2655701. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]