Legumain
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| Legumain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.34 | ||||||||
| CAS broj | 149371-18-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Legumain (EC 3.4.22.34, asparaginska endopeptidaza, citvak, proteinaza B, hemoglobinaza, PRSC1 genski produkt (Homo sapiens), vicilinska peptidohidrolaza, endopeptidaza pasulja, vicilinska peptidohidrolaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza proteina i malih molekulskih supstrata na -Asn-Xaa- vezama
Ovaj enzim je prisutan u mahunama metilja Schistosoma mansoni, i u lizozomima sisara.
Reference[uredi | uredi kod]
- ↑ Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 746-749.
- ↑ Dalton, J.P. and Brindley, P.J. (1998). „Schistosome legumain”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 749-754.
- ↑ Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. (1998). „Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases”. FEBS Lett. 441: 361-365. PMID 9891971.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Dalton, J.P. and Brindley, P.J. (1998). „Schistosome legumain”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 749-754.
- Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes. London: Academic Press. str. 746-749.