LIG4

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Ligaza IV, DNK, ATP-zavisna

PDB prikaz baziran na 1ik9.
Dostupne strukture
1IK9, 2E2W, 3II6
Identifikatori
Simbol LIG4
Vanjski ID OMIM601837 MGI1335098 HomoloGene1736 GeneCards: LIG4 Gene
EC broj 6.5.1.1
Pregled RNK izražavanja
PBB GE LIG4 206235 at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 3981 319583
Ensembl ENSG00000174405 ENSMUSG00000049717
UniProt P49917 Q8BTF5
RefSeq (mRNA) NM_001098268.1 NM_176953.3
RefSeq (protein) NP_001091738.1 NP_795927.2
Lokacija (UCSC) Chr 13:
108.86 - 108.87 Mb
Chr 8:
9.97 - 9.98 Mb
PubMed pretraga [1] [2]

LIG4 je gen koji kodira proteinsku DNK ligazu IV.[1] Ovaj protein je ATP zavisna DNK ligaza koja spaja dvolančane prekide tokom nehomolognog spajanja krajeva u putu popravke prekida dvostrukog lanca. On je takođe esencijalan za V(D)J rekombinaciju.

Defekti ovog gena uzrokuju LIG4 sindrom. Lig4 homolog u kvascu je Dnl4.

Interakcije[uredi - уреди]

Lig4 formira kompleks sa XRCC4,[2][3] i dalje interaguje sa DNK zavisnom proteinskom kinazom (DNA-PK) i XLF/Cernunnos.

Reference[uredi - уреди]

  1. "Entrez Gene: LIG4 ligase IV, DNA, ATP-dependent". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3981. 
  2. Deshpande Rajashree A, Wilson Thomas E (Oct. 2007). "Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4". DNA Repair (Amst.) 6 (10): 1507–16. DOI:10.1016/j.dnarep.2007.04.014. ISSN 1568-7864. PMID 17567543. 
  3. Sibanda B L, Critchlow S E, Begun J, Pei X Y, Jackson S P, Blundell T L, Pellegrini L (Dec. 2001). "Crystal structure of an Xrcc4-DNA ligase IV complex". Nat. Struct. Biol. 8 (12): 1015–9. DOI:10.1038/nsb725. ISSN 1072-8368. PMID 11702069. 

Literatura[uredi - уреди]

  • Wei YF, Robins P, Carter K, et al. (1995). "Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination". Mol. Cell. Biol. 15 (6): 3206–16. PMID 7760816. 
  • Robins P, Lindahl T (1996). "DNA ligase IV from HeLa cell nuclei". J. Biol. Chem. 271 (39): 24257–61. DOI:10.1074/jbc.271.39.24257. PMID 8798671. 
  • Grawunder U, Wilm M, Wu X, et al. (1997). "Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells". Nature 388 (6641): 492–5. DOI:10.1038/41358. PMID 9242410. 
  • Critchlow SE, Bowater RP, Jackson SP (1997). "Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV". Curr. Biol. 7 (8): 588–98. DOI:10.1016/S0960-9822(06)00258-2. PMID 9259561. 
  • Grawunder U, Zimmer D, Leiber MR (1998). "DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains". Curr. Biol. 8 (15): 873–6. DOI:10.1016/S0960-9822(07)00349-1. PMID 9705934. 
  • Grawunder U, Zimmer D, Fugmann S, et al. (1998). "DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytes". Mol. Cell 2 (4): 477–84. DOI:10.1016/S1097-2765(00)80147-1. PMID 9809069. 
  • Riballo E, Critchlow SE, Teo SH, et al. (1999). "Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient". Curr. Biol. 9 (13): 699–702. DOI:10.1016/S0960-9822(99)80311-X. PMID 10395545. 
  • Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–43. DOI:10.1074/jbc.274.53.37538. PMID 10608806. 
  • Nick McElhinny SA, Snowden CM, McCarville J, Ramsden DA (2000). "Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends". Mol. Cell. Biol. 20 (9): 2996–3003. DOI:10.1128/MCB.20.9.2996-3003.2000. PMID 10757784. 
  • Chen L, Trujillo K, Sung P, Tomkinson AE (2000). "Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase". J. Biol. Chem. 275 (34): 26196–205. DOI:10.1074/jbc.M000491200. PMID 10854421. 
  • Lee KJ, Huang J, Takeda Y, Dynan WS (2000). "DNA ligase IV and XRCC4 form a stable mixed tetramer that functions synergistically with other repair factors in a cell-free end-joining system". J. Biol. Chem. 275 (44): 34787–96. DOI:10.1074/jbc.M004011200. PMID 10945980. 
  • Riballo E, Doherty AJ, Dai Y, et al. (2001). "Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity". J. Biol. Chem. 276 (33): 31124–32. DOI:10.1074/jbc.M103866200. PMID 11349135. 
  • Sibanda BL, Critchlow SE, Begun J, et al. (2002). "Crystal structure of an Xrcc4-DNA ligase IV complex". Nat. Struct. Biol. 8 (12): 1015–9. DOI:10.1038/nsb725. PMID 11702069. 
  • O'Driscoll M, Cerosaletti KM, Girard PM, et al. (2002). "DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency". Mol. Cell 8 (6): 1175–85. DOI:10.1016/S1097-2765(01)00408-7. PMID 11779494. 
  • Kuschel B, Auranen A, McBride S, et al. (2002). "Variants in DNA double-strand break repair genes and breast cancer susceptibility". Hum. Mol. Genet. 11 (12): 1399–407. DOI:10.1093/hmg/11.12.1399. PMID 12023982. 
  • Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA (2002). "Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair". Mol. Cell. Biol. 22 (14): 5194–202. DOI:10.1128/MCB.22.14.5194-5202.2002. PMID 12077346. 
  • Roth DB (2002). "Amplifying mechanisms of lymphomagenesis". Mol. Cell 10 (1): 1–2. DOI:10.1016/S1097-2765(02)00573-7. PMID 12150897. 
  • Smogorzewska A, Karlseder J, Holtgreve-Grez H, et al. (2003). "DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2". Curr. Biol. 12 (19): 1635–44. DOI:10.1016/S0960-9822(02)01179-X. PMID 12361565. 
  • Roddam PL, Rollinson S, O'Driscoll M, et al. (2003). "Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination". J. Med. Genet. 39 (12): 900–5. DOI:10.1136/jmg.39.12.900. PMID 12471202. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 

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