L-lizinska ciklodeaminaza

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L-lizinska ciklodeaminaza
Identifikatori
EC broj 4.3.1.28
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

L-lizinska ciklodeaminaza (EC 4.3.1.28, rapL (gen), fkbL (gen), tubZ (gen), visC (gen)) je enzim sa sistematskim imenom L-lizin amonijak-lijaza (ciklizacija, formira amonijak).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-lizin \rightleftharpoons L-pipekolat + NH3

Za dejstvo ovog enzma je neophodan NAD+.

Reference[uredi - уреди]

  1. Khaw, L.E., Bohm, G.A., Metcalfe, S., Staunton, J. and Leadlay, P.F. (1998). "Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase". J. Bacteriol. 180: 809–814. PMID 9473033. 
  2. Gatto, G.J., Jr., Boyne, M.T., 2nd, Kelleher, N.L. and Walsh, C.T. (2006). "Biosynthesis of pipecolic acid by RapL, a lysine cyclodeaminase encoded in the rapamycin gene cluster". J. Am. Chem. Soc. 128: 3838–3847. PMID 16536560. 
  3. Tsotsou, G.E. and Barbirato, F. (2007). "Biochemical characterisation of recombinant Streptomyces pristinaespiralis L-lysine cyclodeaminase". Biochimie 89: 591–604. PMID 17291665. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]