L-iditol 2-dehidrogenaza
| L-iditol 2-dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Tetramer sorbitol dehidrogenaze (čovjek) | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.1.1.14 | ||||||||
| CAS broj | 9028-21-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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L-iditol 2-dehidrogenaza (EC 1.1.1.14, L-iditolna 2-dehidrogenaza, poliol dehidrogenaza, sorbitol dehidrogenaza, L-iditol:NAD+ 5-oksidoreduktaza, L-iditol (sorbitol) dehidrogenaza, glucitol dehidrogenaza, L-iditol:NAD+ oksidoreduktaza, sorbitol dehidrogenaza zavisna od NAD+, NAD+-sorbitol dehidrogenaza) je enzim sa sistematskim imenom L-iditol:NAD+ 2-oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- L-iditol + NAD+ L-sorboza + NADH + H+
Ovaj enzim je šroko distribuiran i poznato je da je prisutan kod arheja, bakterija, kvasaca, biljki i životinja. On deluje na brojne šećerne alkohole, uklučujući L-iditol, D-glucitol, D-ksilitol, i D-galaktitol. Enzimi iz različitih organisma ili tkiva pokazuju različite specifičnosti za supstrate. Ovaj enzim je specifičan za NAD+ i ne može da koristi NADP+.
Reference[uredi | uredi kod]
- ↑ Bailey, J.P., Renz, C. and McGuinness, E.T. (1981). „Sorbitol dehydrogenase from horse liver: purification, characterization and comparative properties”. Comp. Biochem. Physiol. 69B: 909-914.
- ↑ Burnell, J.N. and Holmes, R.S. (1983). „Purification and properties of sorbitol dehydrogenase from mouse liver”. Int. J. Biochem. 15: 507-511. PMID 6852349.
- ↑ Leissing, N. and McGuinness, E.T. (1978). „Rapid affinity purification and properties of rat liver sorbitol dehydrogenase”. Biochim. Biophys. Acta 524: 254-261. PMID 667078.
- ↑ Negm, F.B. and Loescher, W.H. (1979). „Detection and characterization of sorbitol dehydrogenase from apple callus tissue”. Plant Physiol. 64: 69-73. PMID 16660917.
- ↑ O'Brien, M.M., Schofield, P.J. and Edwards, M.R. (1983). „Polyol-pathway enzymes of human brain. Partial purification and properties of sorbitol dehydrogenase”. Biochem. J. 211: 81-90. PMID 6870831.
- ↑ Ng, K., Ye, R., Wu, X.C. and Wong, S.L. (1992). „Sorbitol dehydrogenase from Bacillus subtilis. Purification, characterization, and gene cloning”. J. Biol. Chem. 267: 24989-24994. PMID 1460002.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.