Kvinaprilat

Hinaprilat
Klinički podaci
AHFS/Drugs.com	Monografija
Identifikatori
CAS broj	82768-85-2
ATC kod	nije dodeljen
UNII	34SSX5LDE5
ChEMBL	CHEMBL1733
Hemijski podaci
Formula	C23H26N2O5
Mol. masa	410,463
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C23H26N2O5/c1-15(24-19(22(27)28)12-11-16-7-3-2-4-8-16)21(26)25-14-18-10-6-5-9-17(18)13-20(25)23(29)30/h2-10,15,19-20,24H,11-14H2,1H3,(H,27,28)(H,29,30)/t15-,19-,20-/m0/s1; Key: FLSLEGPOVLMJMN-YSSFQJQWSA-N
Sinonimi	CI-928
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Kvinaprilat je aktivni metabolit kvinaprila.^[2] On je organsko jedinjenje, koje sadrži 23 atoma ugljenika i ima molekulsku masu od 410,463 Da.

Osobine[uredi | uredi kod]

Osobina	Vrednost
Broj akceptora vodonika	6
Broj donora vodonika	3
Broj rotacionih veza	8
Particioni koeficijent^[3] (ALogP)	0,1
Rastvorljivost^[4] (logS, log(mol/L))	-5,3
Polarna površina^[5] (PSA, Å²)	106,9

↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Ferry J J; Horvath A M; Sedman A J; Latts J R; Colburn W A (1987). „Influence of food on the pharmacokinetics of quinapril and its active diacid metabolite, CI-928”. Journal of clinical pharmacology 27 (5): 397–399.
↑ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A 102: 3762-3772. DOI:10.1021/jp980230o.
↑ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488-1493. DOI:10.1021/ci000392t. PMID 11749573.
↑ Ertl P., Rohde B., Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714-3717. DOI:10.1021/jm000942e. PMID 11020286.

Hardman JG, Limbird LE, Gilman AG. (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10 izd.). New York: McGraw-Hill. DOI:10.1036/0071422803. ISBN 0-07-135469-7.
Thomas L. Lemke, David A. Williams, ur. (2007). Foye's Principles of Medicinal Chemistry (6 izd.). Baltimore: Lippincott Willams & Wilkins. ISBN 0-7817-6879-9.

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