Koproporfirinogen dehidrogenaza
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| Koproporfirinogen dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.3.99.22 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Koproporfirinogen dehidrogenaza (EC 1.3.99.22, od kiseonika nezavisna koproporfirinogen-III oksidaza, HemN, radical SAM enzim, koproporfirinogen III oksidaza) je enzim sa sistematskim imenom koproporfirinogen-III:S-adenozil-L-metionin oksidoreduktaza (dekarboksilacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- koproporfirinogen III + 2 S-adenozil-L-metionin protoporfirinogen IX + 2 CO2 + 2 L-metionin + 2 5'-dezoksiadenozin
Ovaj enzim se razlikuje od EC 1.3.3.3, koproporfirinogen oksidaze, po tome što koristi S-adenozil-L-metionin umesto kiseonika kao oksidans. On je prisutan uglavnom kod bakterija, dok eukariote koriste od kiseonika zavisne oksidaze.
Reference[uredi | uredi kod]
- ↑ Layer, G., Verfürth, K., Mahlitz, E. and Jahn, D. (2002). „Oxygen-independent coproporphyrinogen-III oxidase HemN from Escherichia coli”. J. Biol. Chem. 277: 34136-34142. PMID 12114526.
- ↑ Layer, G., Moser, J., Heinz, D.W., Jahn, D. and Schubert, W.D. (2003). „Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes”. EMBO J. 22: 6214-6224. PMID 14633981.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.