Komplementna potkomponenta C1s
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| Komplementna potkomponenta C1s | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.42 | ||||||||
| CAS broj | 80295-70-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Komplementna potkomponenta C1s (EC 3.4.21.42, C1 esteraza, aktivirani komplement C1s, komplement C overbar 1r) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Arg-Ala veze u komplementnoj komponenti C4 čime se formiraju C4a i C4b, i Lys(ili Arg)-Lys veze u komplementnoj komponenti C2 čime se formiraju C2a i C2b: "klasični" put C3 konvertaze
Ovaj enzim se aktivira iz proenzima C1s u plasmi dejstvom komplementne potkomponente C overbar 1r.
Reference[uredi | uredi kod]
- ↑ Sim, R.B. (1981). „T'he human complement system serine proteases C1r and C1s and their proenzymes”. Methods Enzymol. 80: 26-42. PMID 6281620.
- ↑ MacKinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E. (1987). „Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence”. Eur. J. Biochem. 169: 547-553. PMID 3500856.
- ↑ Müller-Eberhard, H.J. (1988). „Molecular organization and function of the complement system”. Annu. Rev. Biochem. 57: 321-347. PMID 3052276.
- ↑ Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C (1989). „1 esterase and acrosin, for peptide p-nitroanilide substrates”. Biochim. Biophys. Acta 996: 89-94. PMID 2500154.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.