KoA-disulfid reduktaza
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| KoA-disulfid reduktaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.8.1.14 | ||||||||
| CAS broj | 206770-55-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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KoA-disulfid reduktaza (EC 1.8.1.14, KoA-disulfidna reduktaza (NADH2), NADH2:KoA-disulfidna oksidoreduktaza, KoA:NAD+ oksidoreduktaza, KoADR, koenzim A disulfidna reduktaza) je enzim sa sistematskim imenom KoA:NAD(P)+ oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2 KoA + NAD(P)+ KoA-disulfid + NAD(P)H + H+
Ova enzim je flavoprotein. On se razlikuje od enzima EC 1.8.1.6 (cistinske reduktaze), EC 1.8.1.7 (glutation-disulfidne reduktaze) i EC 1.8.1.13 (bis-gama-glutamilcistinske reduktaze). Dok enzim iz Staphylococcus aureus ima jaku preferenciju za NADPH, enzim iz termofilne Archaea Pyrococcus horikoshii može da efektivno koristi NADH i NADPH.
Reference[uredi | uredi kod]
- ↑ Setlow, B. and Setlow, P. (1977). „Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium”. J. Bacteriol. 132: 444-452. PMID 410791.
- ↑ delCardayré, S.B., Stock, K.P., Newton, G.L., Fahey, R.C. and Davies, J.E. (1998). „Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus'. Purification and characterization of the native enzyme”. J. Biol. Chem. 273: 5744-5751. PMID 9488707.
- ↑ Luba, J., Charrier, V. and Claiborne, A. (1999). „Coenzyme A-disulfide reductase from Staphylococcus aureus': evidence for asymmetric behavior on interaction with pyridine nucleotides”. Biochemistry 38: 2725-2737. PMID 10052943.
- ↑ Harris, D.R., Ward, D.E., Feasel, J.M., Lancaster, K.M., Murphy, R.D., Mallet, T.C. and Crane, E.J., 3rd. (2005). „Discovery and characterization of a coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles”. FEBS J. 272: 1189-1200. PMID 15720393.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.