Katepsin V

Izvor: Wikipedia
Katepsin V
Identifikatori
EC broj 3.4.22.43
CAS broj 223670-00-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Katepsin V (EC 3.4.22.43, katepsin L2, katepsin U) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Ovaj rekombinantni enzim hidrolizuje proteine (serumski albumin, kolagen) i sintetičke supstrate (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)

Katepsin V je ljudska lizozomalna cisteinska endopeptidaza iz familije C1 (papainske familije) koja je maksimalno aktivna na pH 5m7 i nestabilna na neutralnom pH.

Reference[uredi - уреди]

  1. Brömme, D., Li, Z., Barnes, M. and Mehler, E. (1999). "Human cathepsin V functional expression, tissue distribution, electrostatic surface potential, enzymatic characterization, and chromosomal localization". Biochemistry 38: 2377–2385. PMID 10029531. 
  2. Adachi, W., Kawamoto, S., Ohno, I., Nishida, K., Kinoshita, S., Matsubara, K. and Okubo, K. (1998). "Isolation and characterization of human cathepsin V: a major proteinase in corneal epithelium". Invest. Ophthalmol. Vis. Sci. 39: 1789–1796. PMID 9727401. 
  3. Santamaría, I., Velasco, G., Cazorla, M., Fueyo, A., Campo, E. and López-Otín, C. (1998). "Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas". Cancer Res. 58: 1624–1630. PMID 9563472. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]