Katepsin B

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Katepsin B
PDB 1csb EBI.jpg
Identifikatori
EC broj 3.4.22.1
CAS broj 9047-22-7
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Katepsin B (EC 3.4.22.1, katepsin B1, katepsin II) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina sa širokom specifičšću za peptidne veze. Preferentno dolazi do razlaganja -Arg-Arg- veza u malim molekulskim supstratima (po čeme se razlikuje od katepsina L).

Ovaj intraćelijski (lizozomalni) enzim pripada peptidaznoj familiji C1 (papainskoj familiji)

Reference[uredi - уреди]

  1. Bond, J.S. and Barrett, A.J. (1980). "Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. A further example of peptidyldipeptidase activity of this proteinase". Biochem. J. 189: 17–25. PMID 7458901. 
  2. Barrett, A.J. and Kirschke, H. (1981). "Cathepsin B, cathepsin H and cathepsin L". Methods Enzymol. 80: 535–561. PMID 7043200. 
  3. Polgár, L. and Csoma, C. (1987). "Dissociation of ionizing groups in the binding cleft inversely controls the endo- and exopeptidase activities of cathepsin B". J. Biol. Chem. 262: 14448–14453. PMID 3312190. 
  4. Barrett, A.J., Buttle, D.J. and Mason, R.W. (1988). "Lysosomal cysteine proteinases". ISI Atlas of Science. Biochemistry 1: 256–260. 
  5. Kirschke, H., Wikstrom, P. and Shaw, E. (1988). "Active center differences between cathepsins L and B: the S1 binding region". FEBS Lett. 228: 128–130. PMID 3342870. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]