Karboksipeptidaza C
(Preusmjereno sa stranice Katepsin A)
| Karboksipeptidaza C | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.16.5 | ||||||||
| CAS broj | 9046-67-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Karboksipeptidaza C (EC 3.4.16.5, karboksipeptidaza Y, serinska karboksipeptidaza I, katepsin A, lizozomalni protektivni protein, deamidaza, lizozomalna karboksipeptidaza A, fazeolin) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje C-terminalne aminokiseline sa širokom specifičnošću
Ova karboksipeptidaza optimalno deluje na pH 4.5-6.0. Inhibira je diizopropil fluorofosfat, i senzitivna je na tiol-blokirajuće reagense.
Reference[uredi | uredi kod]
- ↑ Breddam, K. (1986). „Serine carboxypeptidases. A review”. Carlsberg Res. Commun. 51: 83-128.
- ↑ Valls, L.A., Hunter, C.P., Rothman, J.H. and Stevens, T.H. (1987). „Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide”. Cell 48: 887-897. PMID 3028649.
- ↑ Jackman, H.L., Morris, P.W., Deddish, P.A., Skidgel, R.A. and Erdös, E.G. (1992). „Inactivation of endothelin I by deamidase (lysosomal protective protein)”. J. Biol. Chem. 267: 2872-2875. PMID 1737744.
- ↑ Miller, J.J., Changaris, D.G. and Levy, R.S. (1992). „Purification, subunit structure and inhibitor profile of cathepsin-A”. J. Chromatogr. 627: 153-162. PMID 1487525.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.