Kaspaza-7
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| Kaspaza-7 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.60 | ||||||||
| CAS broj | 189258-14-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kaspaza-7 (EC 3.4.22.60, CASP-7, ICE-slična apoptotička proteaza 3, ICE-LAP3, apoptotička proteaza Mch-3, Mch3, CMH-1) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Asp-Glu-Val-Asp-
Kaspaza-7 je efektor/izvršilac kaspaze, kao što su i kaspaza-3 (EC 3.4.22.56) i kaspaza-6 (EC 3.4.22.59).
Reference[uredi | uredi kod]
- ↑ Chang, H.Y. and Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821-846. PMID 11104820.
- ↑ Nicholson, D. and Thornberry, N.A. (2004). „Caspase-3 and caspase-7”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1298-1302.
- ↑ Fang, B., Boross, P.I., Tozser, J. and Weber, I.T. (2006). „Structural and kinetic analysis of caspase-3 reveals role for S5 binding site in substrate recognition”. J. Mol. Biol. 360: 654-666. PMID 16781734.
- ↑ Denault, J.B. and Salvesen, G.S. (2003). „Human caspase-7 activity and regulation by its N-terminal peptide”. J. Biol. Chem. 278: 34042-34050. PMID 12824163.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Nicholson, D. and Thornberry, N.A. (2004). „Caspase-3 and caspase-7”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1298-1302.