Karnozinska sintaza

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Karnozinska sintaza
Identifikatori
EC broj 6.3.2.11
CAS broj 9023-61-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum

Karnozinska sintaza (EC 6.3.2.11, karnozinska sintetaza, karnozin-anserinska sintetaza, homokarnozin-karnozinska sintetaza, karnozin-homokarnozinska sintetaza, L-histidin:beta-alanin ligaza (formira AMP)) je enzim sa sistematskim imenom L-histidin:beta-alanin ligaza (formira ADP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-histidin + beta-alanin ADP + fosfat + karnozin

Ova enzim formira ADP.

Reference[uredi | uredi kod]

  1. Kalyankar, G.D. and Meister, A. (1959). „Enzymatic synthesis of carnosine and related β-alanyl and γ-aminobutyryl peptides”. J. Biol. Chem. 234: 3210-3218. PMID 14404206. 
  2. Stenesh, J.J. and Winnick, T. (1960). „Carnosine-anserine synthetase of muscle. 4. Partial purification of the enzyme and further studies of β-alanyl peptide synthesis”. Biochem. J. 77: 575-581. PMID 16748858. 
  3. Crush, K.G. (1970). „Carnosine and related substances in animal tissues”. Comp. Biochem. Physiol. 34: 3-30. PMID 4988625. 
  4. Drozak, J., Veiga-da-Cunha, M., Vertommen, D., Stroobant, V. and Van Schaftingen, E. (2010). „Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1)”. J. Biol. Chem. 285: 9346-9356. PMID 20097752. 

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