Karboprost

Karboprost
(IUPAC) ime
	(5Z,9α,11α,13E,15S)-9,11,15-trihidroksi-15- metilprosta-5,13-dien-1-oinska kiselina
Klinički podaci
AHFS/Drugs.com	Mikromedeks, detaljne potrošačke informacije
MedlinePlus	a600042
Identifikatori
CAS broj	58551-69-2
ATC kod	G02AD04
PubChem	5281075
DrugBank	DB00429
ChemSpider	4444532
UNII	U4526F86FJ
ChEMBL	CHEMBL1201299
Hemijski podaci
Formula	C21H36O5
Mol. masa	368,508 g/mol
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C21H36O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,18+,19-,21+/m1/s1 ; Key: DLJKPYFALUEJCK-IIELGFQLSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	℞ Prescription only
Način primene	Intravenozno

Karboprost (Hemabat, Tam) je sintetički prostaglandinski analog PGF_2α (specifično, on je 15-metil-PGF_2α) sa oksitoksnim svojstvima.

Karboprost indukuje kontrakcije i može da inicira abortus u ranoj trudnoći. On takođe redukuje porođajno krvarenje.

Indikacije[uredi | uredi kod]

Koristi se za kontrolu porođajnog krvarenja uzrokovanog atonijom materice, koje se ne može kontrolisati drugim metodima.

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

Indman P (2004). „Use of carboprost to facilitate hysteroscopic resection of submucous myomas”. J Am Assoc Gynecol Laparosc 11 (1): 68–72. DOI:10.1016/S1074-3804(05)60014-X. PMID 15104835.
Vukelić J (2001). „Second trimester pregnancy termination in primigravidas by double application of dinoprostone gel and intramuscular administration of carboprost tromethamine”. Med Pregl 54 (1–2): 11–6. PMID 11436877.
Ippoliti C, Przepiorka D, Mehra R, Neumann J, Wood J, Claxton D, Gajewski J, Khouri I, van Besien K, Andersson B (1995). „Intravesicular carboprost for the treatment of hemorrhagic cystitis after marrow transplantation”. Urology 46 (6): 811–5. DOI:10.1016/S0090-4295(99)80349-5. PMID 7502421.

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