Karboksipeptidaza M
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| Karboksipeptidaza M | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.17.12 | ||||||||
| CAS broj | 120038-28-0 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Karboksipeptidaza M (EC 3.4.17.12, CPM) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje C-terminalnih argininskih i lizinskih ostataka sa polipeptida
Ovaj membranski enzim je optimalno aktivan pri neutralnom pH.
Reference[uredi | uredi kod]
- ↑ Skidgel, R.A. (1988). „Basic carboxypeptidases: Regulators of peptide hormone activity”. Trends Pharmacol. Sci. 9: 303-304. PMID 3074547.
- ↑ Deddish, P.A., Skidgel, R.A. and Erdös, E.G. (1989). „Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH”. Biochem. J. 261: 289-291. PMID 2775217.
- ↑ Skidgel, R.A., Davis, R.M. and Tan, F. (1989). „Human carboxypeptidase M. Purification and characterization of membrane-bound carboxypeptidase that cleaves peptide hormones”. J. Biol. Chem. 264: 2236-2241. PMID 2914904.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.