Kapa-karaginaza
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| Kapa-karaginaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.1.83 | ||||||||
| CAS broj | 37288-59-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Kapa-karaginaza (EC 3.2.1.83, kapa-karaginan 4-beta-D-glikanohidrolaza) je enzim sa sistematskim imenom kapa-karaginan 4-beta-D-glikanohidrolaza (zadržavanje konfiguracije).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endohidroliza (1->4)-beta-D-veza između D-galaktoza 4-sulfata i 3,6-anhidro-D-galaktoze u kapa-karagenanima
Glavni produkti hidrolize su neokarabioza-sulfat i neokaratetraoza-sulfat.
Reference[uredi | uredi kod]
- ↑ Weigl, J. and Yashe, W. (1966). „The enzymic hydrolysis of carrageenan by Pseudomonas carrageenovora: purification of a κ-carrageenase”. Can. J. Microbiol. 12: 939-947. PMID 5972647.
- ↑ Potin, P., Sanseau, A., Le Gall, Y., Rochas, C. and Kloareg, B. (1991). „Purification and characterization of a new κ-carrageenase from a marine Cytophaga-like bacterium”. Eur. J. Biochem. 201: 241-247. PMID 1915370.
- ↑ Potin, P., Richard, C., Barbeyron, T., Henrissat, B., Gey, C., Petillot, Y., Forest, E., Dideberg, O., Rochas, C. and Kloareg, B. (1995). „Processing and hydrolytic mechanism of the cgkA-encoded κ-carrageenase of Alteromonas carrageenovora”. Eur. J. Biochem. 228: 971-975. PMID 7737202.
- ↑ Michel, G., Barbeyron, T., Flament, D., Vernet, T., Kloareg, B. and Dideberg, O. (1999). „Expression, purification, crystallization and preliminary x-ray analysis of the κ-carrageenase from Pseudoalteromonas carrageenovora”. Acta Crystallogr. D Biol. Crystallogr. 55: 918-920. PMID 10089334.
- ↑ Michel, G., Chantalat, L., Duee, E., Barbeyron, T., Henrissat, B., Kloareg, B. and Dideberg, O. (2001). „The κ-carrageenase of P. carrageenovora features a tunnel-shaped active site: a novel insight in the evolution of Clan-B glycoside hydrolases”. Structure 9: 513-525. PMID 11435116.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.