Kalicivirin
Prijeđi na navigaciju
Prijeđi na pretragu
| Kalicivirin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.66 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kalicivirin (EC 3.4.22.66, Camberwell virus procesujuća peptidaza, Chiba virus procesujuća peptidaza, Norwalk virus procesujuća peptidaza, Southampton virus procesujuća peptidaza, norovirus virus procesujuća peptidaza, calicivirus tripsinu-slična cisteinska proteaza, calicivirus TCP, calicivirus 3C-slična proteaza, calicivirus endopeptidaza, 3C endopeptidaza virusa bolesti zečje bolesti krvarenja) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Endopeptidaza sa a preference for cleavage when the P1 pozicija is occupied by Glu- and the P1' pozicija is occupied by Gly-
Virusi koji su članovi Norovirusnog roda (Caliciviridae familije) su glavni uzrok epidemijskog akutnog viralnog gastroenteritisa.
Reference[uredi | uredi kod]
- ↑ Meyers, G., Rossi, C. and Thiel, H.J. (2004). „Calicivirus endopeptidases”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1380-1382.
- ↑ Wirblich, C., Sibilia, M., Boniotti, M.B., Rossi, C., Thiel, H.J. and Meyers, G. (1995). „3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity”. J. Virol. 69: 7159-7168. PMID 7474137.
- ↑ Martín Alonso, J.M., Casais, R., Boga, J.A. and Parra, F. (1996). „Processing of rabbit hemorrhagic disease virus polyprotein”. J. Virol. 70: 1261-1265. PMID 8551592.
- ↑ Liu, B., Clarke, I.N. and Lambden, P.R. (1996). „Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis”. J. Virol. 70: 2605-2610. PMID 8642693.
- ↑ Liu, B.L., Viljoen, G.J., Clarke, I.N. and Lambden, P.R. (1999). „Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli”. J. Gen. Virol. 80: 291-296. PMID 10073687.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Meyers, G., Rossi, C. and Thiel, H.J. (2004). „Calicivirus endopeptidases”. u: Barrett, A.J., Rawlings, N.D. and Woessner, J.F.. Handbook of Proteolytic Enzymes (2nd izd.). London: Elsevier. str. 1380-1382.