Jararhagin
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| Jararhagin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.24.73 | ||||||||
| CAS broj | 160477-79-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Jararhagin (EC 3.4.24.73, HF2-proteinaza, JF1) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza -His10-Leu-, -Ala14-Leu-, -Tyr16-Leu- i -Phe24-Phe- veza u insulinskom B lancu
Ova hemoragička endopeptidaza je prisutna u venumu zmije Bothrops jararaca.
Reference[uredi | uredi kod]
- ↑ Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). „Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca”. u: Ohsaka, A., Hayashi, K. and Sawai, Y.. Animal, Plant and Microbial Toxins. New York: Plenum Press. str. 111-121.
- ↑ Assakura, M.T., Reichl, A.P. and Mandelbaum, F.R. (1986). „Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)”. Toxicon 24: 943-946. PMID 3810664.
- ↑ Paine, M.J.I., Desmond, H.P., Theakston, R.D.G. and Crampton, J.M. (1992). „Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family”. J. Biol. Chem. 267: 22869-22876. PMID 1385408.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). „Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca”. u: Ohsaka, A., Hayashi, K. and Sawai, Y.. Animal, Plant and Microbial Toxins. New York: Plenum Press. str. 111-121.