Indolamin 2,3-dioksigenaza

Izvor: Wikipedia
Indolamin 2,3-dioksigenaza
Identifikatori
EC broj 1.13.11.52
CAS broj 9014-51-1
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Indolamin 2,3-dioksigenaza (EC 1.13.11.52, IDO (nespecifična), triptofanska pirolaza (nespecifična)) je enzim sa sistematskim imenom D-triptofan:kiseonik 2,3-oksidoreduktaza (deciklizacija).[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju

(1) D-triptofan + O2 \rightleftharpoons N-formil-D-kinurenin
(2) L-triptofan + O2 \rightleftharpoons N-formil-L-kinurenin

Ovaj enzim je protohemoprotein. Za njegovo dejstvo je neophodna askorbinska kiselina i metilin plavo.

Reference[uredi - уреди]

  1. Yamamoto, S. and Hayaishi, O. (1967). "Tryptophan pyrrolase of rabbit intestine. D- and L-tryptophan-cleaving enzyme or enzymes". J. Biol. Chem. 242: 5260–5266. PMID 6065097. 
  2. Yasui, H., Takai, K., Yoshida, R. and Hayaishi, O. (1986). "Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients". Proc. Natl. Acad. Sci. USA 83: 6622–6626. PMID 2428037. 
  3. Takikawa, O., Yoshida, R., Kido, R. and Hayaishi, O. (1986). "Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase". J. Biol. Chem. 261: 3648–3653. PMID 2419335. 
  4. Hirata, F., Ohnishi, T. and Hayaishi, O. (1977). "Indoleamine 2,3-dioxygenase. Characterization and properties of enzyme. O2- complex". J. Biol. Chem. 252: 4637–4642. PMID 194886. 
  5. Dang, Y., Dale, W.E. and Brown, O.R. (2000). "Comparative effects of oxygen on indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase of the kynurenine pathway". Free Radic. Biol. Med. 28: 615–624. PMID 10719243. 
  6. Littlejohn, T.K., Takikawa, O., Truscott, R.J. and Walker, M.J. (2003). "Asp274 and His346 are essential for heme binding and catalytic function of human indoleamine 2,3-dioxygenase". J. Biol. Chem. 278: 29525–29531. PMID 12766158. 
  7. Thomas, S.R. and Stocker, R. (1999). "Redox reactions related to indoleamine 2,3-dioxygenase and tryptophan metabolism along the kynurenine pathway". Redox Rep. 4: 199–220. PMID 10731095. 
  8. Sono, M. (1990). "Spectroscopic and equilibrium studies of ligand and organic substrate binding to indolamine 2,3-dioxygenase". Biochemistry 29: 1451–1460. PMID 2334706. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]