IkB kinaza

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IkB kinaza
Identifikatori
EC broj 2.7.11.10
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

IkB kinaza (EC 2.7.11.10, CHUK, IKBKA, IKBKB, IKK, IKK-1, IKK-2, inhibitor of NFkapaB kinaza, inhibitor NF-kappaB kinaza, STK12, TANK-vezujući kinaza 1, TBK1) je enzim sa sistematskim imenom ATP:(IkappaB protein) fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + [IkapaB protein] \rightleftharpoons ADP + [IkapaB fosfoprotein]

Ovaj enzim fosforiliše IkapaB proteine na specifičnim serinskim ostacima.

Reference[uredi - уреди]

  1. Regnier, C.H., Song, H.Y., Gao, X., Goeddel, D.V., Cao, Z. and Rothe, M. (1997). "Identification and characterization of an IkappaB kinase". Cell 90: 373–383. PMID 9244310. 
  2. Mercurio, F., Zhu, H., Murray, B.W., Shevchenko, A., Bennett, B.L., Li, J., Young, D.B., Barbosa, M., Mann, M., Manning, A. and Rao, A. (1997). "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation". Science 278: 860–866. PMID 9346484. 
  3. Zandi, E., Rothwarf, D.M., Delhase, M., Hayakawa, M. and Karin, M. (1997). "The IkappaB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IkappaB phosphorylation and NF-kappaB activation". Cell 91: 243–252. PMID 9346241. 
  4. Viatour, P., Merville, M.P., Bours, V. and Chariot, A. (2005). "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation". Trends Biochem. Sci. 30: 43–52. PMID 15653325. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]