Hidroksimetilbilan sintaza

Izvor: Wikipedia
Hidroksimetilbilan sintaza
Protein HMBS PDB 3ECR.png
Identifikatori
EC broj 2.5.1.61
CAS broj 9074-91-3
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Hidroksimetilbilan sintaza (EC 2.5.1.61, HMB-sintaza, porphobilinogen deaminaza, pre-uroporfirinogen sintaza, uroporfirinogen I sintaza, uroporfirinogen I sintetaza, uroporfirinogen sintaza, uroporfirinogen sintetaza, porfobilinogen amonijak-lijaza (polimerizacija), (4-(2-karboksietil)-3-(karboksimetil)pirol-2-il)metiltransferaza (hidrolizacija)) je enzim sa sistematskim imenom porfobilinogen:(4-(2-karboksietil)-3-(karboksimetil)pirrol-2-il)metiltransferaza (hidroliza).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

4 porfobilinogen +H2O \rightleftharpoons hidroksimetilbilan + 4 NH3

Ovaj enzim deluje putem postepene adicije pirolilmetilnih grupa.

Reference[uredi - уреди]

  1. Battersby, A.R., Fookes, C.J.R., Matcham, G.W.J. and McDonald, E. (1980). "Biosynthesis of the pigments of life: formation of the macrocycle". Nature 285: 17–21. PMID 6769048. 
  2. Frydman, R.B. and Feinstein, G. (1974). "Studies on porphobilinogen deaminase and uroporphyrinogen 3 cosynthase from human erythrocytes". Biochim. Biophys. Acta 350: 358–373. PMID 4847568. 
  3. Levin, E.Y. and Coleman, D.L. (1967). "The enzymatic conversion of porphobilinogen to uroporphyrinogen catalyzed by extracts of hematopoietic mouse spleen". J. Biol. Chem. 242: 4247–4253. PMID 6061709. 
  4. Warren, M.J. and Jordan, P.M. (1988). "Investigation into the nature of substrate binding to the dipyrromethane cofactor of Escherichia coli porphobilinogen deaminase". Biochemistry 27: 9020–9030. PMID 3069132. 
  5. Miller, A.D., Hart, G.J., Packman, L.C. and Battersby, A.R. (1988). "Evidence that the pyrromethane cofactor of hydroxymethylbilane synthase (porphobilinogen deaminase) is bound to the protein through the sulphur atom of cysteine-242". Biochem. J. 254: 915–918. PMID 3196304. 
  6. Battersby, A.R. (2000). "Tetrapyrroles: the pigments of life". Nat. Prod. Rep. 17: 507–526. PMID 11152419. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]