HDAC7A

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Histonska deacetilaza 7A

PDB prikaz baziran na 2nvr.
Dostupne strukture
2nvr, 2pqo, 2pqp
Identifikatori
Simboli HDAC7A; HDAC7; DKFZP586J0917
Vanjski ID OMIM606542 MGI1891835 HomoloGene9124 GeneCards: HDAC7A Gene
Pregled RNK izražavanja
PBB GE HDAC7A 217937 s at tn.png
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 51564 56233
Ensembl ENSG00000061273 ENSMUSG00000022475
UniProt Q8WUI4 Q1EDY4
RefSeq (mRNA) NM_015401 XM_001003277
RefSeq (protein) NP_056216 XP_001003277
Lokacija (UCSC) Chr 12:
46.46 - 46.5 Mb
Chr 15:
97.62 - 97.66 Mb
PubMed pretraga [1] [2]

HDAC7A, histonska deacetilaza 7 je enzim koji je kod čoveka kodiran HDAC7 genom.[1][2][3]

Histoni imaju kritičnu ulogu u transkripcionoj regulaciji, progresu ćelijskog ciklusa, i razvojnim stupnjevima. Histonska acetilacija/deacetilacija menja strukturu hromozoma i uslovljava pristup transkripcionih faktora do DNK. Protein kodiran ovim genom je sekventno homologan sa članovima familije histon deacetilaza. Ovaj gen je ortologan sa HDAC7 genom miša, čiji protein promoviše represiju posredovanu transkripcionim korepresorom SMRT. Multiple alternativno splajsovane transkriptne varijante koje kodiraju nekoliko izoformi su nađene.[3]

Interakcije[uredi - уреди]

Za HDAC7A je bilo pokazano da interaguje sa endotelinskim receptorom tipa A,[4] HDAC3,[5] HTATIP,[6] BCL6,[7] nuklearnim receptorskim korepresorom 1[5] i IKZF1.[8]

Vidi još[uredi - уреди]

Literatura[uredi - уреди]

  1. Marks PA, Richon VM, Rifkind RA (Aug 2000). "Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells". J Natl Cancer Inst 92 (15): 1210–6. DOI:10.1093/jnci/92.15.1210. PMID 10922406. 
  2. Kao HY, Downes M, Ordentlich P, Evans RM (Feb 2000). "Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression". Genes Dev 14 (1): 55–66. PMID 10640276. 
  3. 3.0 3.1 "Entrez Gene: HDAC7A histone deacetylase 7A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51564. 
  4. Lee, H J; Chun M, Kandror K V (May. 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". J. Biol. Chem. 276 (20): 16597–600. DOI:10.1074/jbc.C000909200. ISSN 0021-9258. PMID 11262386. 
  5. 5.0 5.1 Fischle, W; Dequiedt F, Fillion M, Hendzel M J, Voelter W, Verdin E (Sep. 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. DOI:10.1074/jbc.M104935200. ISSN 0021-9258. PMID 11466315. 
  6. Xiao, Hui; Chung Jin, Kao Hung-Ying, Yang Yu-Chung (Mar. 2003). "Tip60 is a co-repressor for STAT3". J. Biol. Chem. 278 (13): 11197–204. DOI:10.1074/jbc.M210816200. ISSN 0021-9258. PMID 12551922. 
  7. Lemercier, Claudie; Brocard Marie-Paule, Puvion-Dutilleul Francine, Kao Hung-Ying, Albagli Olivier, Khochbin Saadi (Jun. 2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. DOI:10.1074/jbc.M201736200. ISSN 0021-9258. PMID 11929873. 
  8. Koipally, Joseph; Georgopoulos Katia (Aug. 2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. 277 (31): 27697–705. DOI:10.1074/jbc.M201694200. ISSN 0021-9258. PMID 12015313. 

Dodatna literatura[uredi - уреди]

  • Verdin E, Dequiedt F, Kasler HG (2003). "Class II histone deacetylases: versatile regulators.". Trends Genet. 19 (5): 286–93. DOI:10.1016/S0168-9525(03)00073-8. PMID 12711221. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Lee HJ, Chun M, Kandror KV (2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in downstream signaling". J. Biol. Chem. 276 (20): 16597–600. DOI:10.1074/jbc.C000909200. PMID 11262386. 
  • Fischle W, Dequiedt F, Fillion M, et al. (2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. DOI:10.1074/jbc.M104935200. PMID 11466315. 
  • Lemercier C, Brocard MP, Puvion-Dutilleul F, et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. DOI:10.1074/jbc.M201736200. PMID 11929873. 
  • Bryant H, Farrell PJ (2002). "Signal Transduction and Transcription Factor Modification during Reactivation of Epstein-Barr Virus from Latency". J. Virol. 76 (20): 10290–8. DOI:10.1128/JVI.76.20.10290-10298.2002. PMID 12239305. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932. 
  • Xiao H, Chung J, Kao HY, Yang YC (2003). "Tip60 is a co-repressor for STAT3". J. Biol. Chem. 278 (13): 11197–204. DOI:10.1074/jbc.M210816200. PMID 12551922. 
  • Dequiedt F, Kasler H, Fischle W, et al. (2003). "HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis". Immunity 18 (5): 687–98. DOI:10.1016/S1074-7613(03)00109-2. PMID 12753745. 
  • Lee CH, Chawla A, Urbiztondo N, et al. (2003). "Transcriptional repression of atherogenic inflammation: modulation by PPARdelta". Science 302 (5644): 453–7. DOI:10.1126/science.1087344. PMID 12970571. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Li X, Song S, Liu Y, et al. (2004). "Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins". J. Biol. Chem. 279 (33): 34201–8. DOI:10.1074/jbc.M405179200. PMID 15166223. 
  • Kato H, Tamamizu-Kato S, Shibasaki F (2004). "Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity". J. Biol. Chem. 279 (40): 41966–74. DOI:10.1074/jbc.M406320200. PMID 15280364. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. DOI:10.1073/pnas.0404720101. PMID 15302935. 
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. DOI:10.1016/j.cub.2004.07.051. PMID 15324660. 

Spoljašnje veze[uredi - уреди]