Granzim B

Izvor: Wikipedia
Granzim B
Identifikatori
EC broj 3.4.21.79
CAS broj 143180-74-9
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Granzim B (EC 3.4.21.79, CTLA1, CCPII, citotoksna ćelijska proteinaza-1, granzim G, granzim H, CCP1 proteinaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Preferentno odvajanje: -Asp- >> -Asn- > -Met-, -Ser-

Ovaj enzim je prisutan u citotoksičnim T limfocitnim granulama.

Reference[uredi - уреди]

  1. Schmid, J. and Weissmann, C. (1987). "Induction of mRNA for a serine protease and a β-thromboglobulin-like protein in mitogen-stimulated human leukocytes". J. Immunol. 139: 250–256. PMID 2953813. 
  2. Odake, S., Kam, C.-M., Narasimhan, L., Poe, M., Blake, J.T., Krahenbuhl, O., Tschopp, J. and Powers, J.C. (1991). "Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins". Biochemistry 30: 2217–2227. PMID 1998680. 
  3. Poe, M., Blake, J.T., Boulton, D.A., Gammon, M., Sigal, N.H., Wu, J.K. and Zweerink, H.J. (1991). "Human cytotoxic lymphocyte granzyme B. Its purification from granules and the characterization of substrate and inhibitor specificity". J. Biol. Chem. 266: 98–103. PMID 1985927. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]