Glutation transferaza

Izvor: Wikipedia
Glutation transferaza
GST-wiki.jpg
Identifikatori
EC broj 2.5.1.18
CAS broj 50812-37-8
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glutation transferaza (EC 2.5.1.18, glutation S-transferaza, glutation S-alkiltransferaza, glutation S-ariltransferaza, S-(hidroksialkil)glutation lijaza, glutation S-aralkiltransferaza, glutation S-alkil transferaza, GST) je enzim sa sistematskim imenom RX:glutation R-transferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

RX + glutation \rightleftharpoons HX + R-S-glutation

Ova grupa enzima ima široku specifičnost. R može da bude alifatična, aromatična ili heterociklična grupa; X može da bude sulfatna, nitrilna ili halidna grupa.

Reference[uredi - уреди]

  1. Habig, W.H., Pabst, M.J. and Jakoby, W.B. (1974). "Glutathione S-transferases. The first enzymatic step in mercapturic acid formation". J. Biol. Chem. 249: 7130–7139. PMID 4436300. 
  2. Jakoby, W.B. (1978). "The glutathione S-transferases: a group of multifunctional detoxification proteins". Adv. Enzymol. Relat. Areas Mol. Biol. 46: 383–383. PMID 345769. 
  3. Jakoby, W.B. (1985). "Glutathione transferases: an overview". Methods Enzymol. 113: 495–499. PMID 4088070. 
  4. Keen, J.H. and Jakoby, W.B. (1978). "Glutathione transferases. Catalysis of nucleophilic reactions of glutathione". J. Biol. Chem. 253: 5654–5657. PMID 670218. 
  5. Sheehan, D., Meade, G., Foley, V.M. and Dowd, C.A. (2001). "Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily". Biochem. J. 360: 1–16. PMID 11695986. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]