Glutamatna karboksipeptidaza
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| Glutamatna karboksipeptidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.17.11 | ||||||||
| CAS broj | 9074-87-7 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutamatna karboksipeptidaza (EC 3.4.17.11, karboksipeptidaza G, karboksipeptidaza G1, karboksipeptidaza G2, glutamilna karboksipeptidaza, N-pteroil-L-glutamat hidrolaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje C-terminalnih glutamatnih ostataka sa širokog opsega N-acilacovanih grupa, uključujući peptidil, aminoacil, benzoil, benziloksikarbonil, folil i pteroil grupe
Ovaj cinkov enzim proizvodi Pseudomonadaceae, Flavobakterija sp. i Acinetobacter sp.
Reference[uredi | uredi kod]
- ↑ Goldman, P. and Levy, C.C. (1967). „Carboxypeptidase G: purification and properties”. Proc. Natl Acad. Sci. USA 58: 1299-1306. PMID 5237864.
- ↑ McCullogh, J.L., Chabner, B.A. and Bertino, J.R. (1971). „Purification and properties of carboxypeptidase G1”. J. Biol. Chem. 246: 7207-7213. PMID 5129727.
- ↑ Albrecht, A.M., Boldizar, E. and Hutchinson, D.J. (1978). „Carboxypeptidase displaying differential velocity in hydrolysis of methotrexate, 5-methyltetrahydrofolic acid, and leucovorin”. J. Bacteriol. 134: 506-513. PMID 26657.
- ↑ Sherwood, R.F., Melton, R.G. and Alwan, S.A. (1985). „Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16”. Eur. J. Biochem. 148: 447-453. PMID 3838935.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.