Glikozilfosfatidilinozitolna fosfolipaza D
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| Glikozilfosfatidilinozitolna fosfolipaza D | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.4.50 | ||||||||
| CAS broj | 113756-14-2 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glikozilfosfatidilinozitolna fosfolipaza D (EC 3.1.4.50, GPI-PLD, glikoproteinska fosfolipaza D, fosfatidilinozitolna fosfolipaza D, fosfatidilinozitol-specifična fosfolipaza D) je enzim sa sistematskim imenom glikoprotein-fosfatidilinozitol fosfatidohidrolaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 6-(alfa-D-glukozaminil)-1-fosfatidil-1D-mio-inozitol + H2O 6-(alfa-D-glukozaminil)-1D-mio-inozitol + 3-sn-fosfatidat
Ovaj enzim je takođe aktivan kad je O-4 glukozamina supstituisan oligosaharidom.
Reference[uredi | uredi kod]
- ↑ Low, M.G. and Prasad, A.R.S. (1988). „A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma”. Proc. Natl. Acad. Sci. USA 85: 980-984. PMID 3422494.
- ↑ Malik, A.-S. and Low, M.G. (1986). „Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases”. Biochem. J. 240: 519-527. PMID 3028377.
- ↑ Li, J.Y., Hollfelder, K., Huang, K.S. and Low, M.G. (1994). „Structural features of GPI-specific phospholipase D revealed by fragmentation and Ca2+ binding studies”. J. Biol. Chem. 269: 28963-28971. PMID 7961859.
- ↑ Deeg, M.A, Vierman, E.L. and Cheung, M.C. (2001). „GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex”. J. Lipid Res. 42: 442-451. PMID 11254757.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.