Glikolipid 6-a-manoziltransferaza

Izvor: Wikipedia
Glikolipid 6-a-manoziltransferaza
Identifikatori
EC broj 2.4.1.232
CAS broj 346003-17-6
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Glikolipid 6-a-manoziltransferaza (EC 2.4.1.232, alfa-1,6-manoziltransferaza, GDP-manoza:oligosaharid 1,6-alfa-D-manoziltransferaza, GDP-manoza:glikolipid 1,6-alfa-D-manoziltransferaza, glikolipid 6-alfa-manoziltransferaza, GDP-manoza:oligosaharid 1,6-alfa-D-manoziltransferaza) je enzim sa sistematskim imenom GDP-manoza:oligosaharid 6-alfa-D-manoziltransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju

Prenosi alfa-D-manozilni ostatak sa GDP-manoze na oligosaharid vezan za lipid, formira alfa-(1->6)-D-manozil-D-manoznu vezu

Za dejstvo ovog enzima je neophodan Mn2+. Kod Saccharomyces cerevisiae ovaj enzim katalizuje esencijalni korak elongacije spoljašnjeg lanca N-vezanih oligosaharida. Man8GlcNAc i Man9GlcNAc su jednako dobri supstrati.

Reference[uredi - уреди]

  1. Romero, P.A. and Herscovics, A. (1989). "Glycoprotein biosynthesis in Saccharomyces cerevisiae. Characterization of α-1,6-mannosyltransferase which initiates outer chain formation". J. Biol. Chem. 264: 1946–1950. PMID 2644248. 
  2. Reason, A.J., Dell, A., Romero, P.A. and Herscovics, A. (1991). "Specificity of the mannosyltransferase which initiates outer chain formation in Saccharomyces cerevisiae". Glycobiology 1: 387–391. PMID 1820199. 
  3. Nakanishi-Shindo, Y., Nakayama, K., Tanaka, A., Toda, Y. and Jigami, Y. (1993). "Structure of the N-linked oligosaccharides that show the complete loss of α-1,6-polymannose outer chain from och1, och1 mnn1, and och1 mnn1 alg3 mutants of Saccharomyces cerevisiae". J. Biol. Chem. 268: 26338–26345. PMID 8253757. 
  4. Yamamoto, K., Okamoto, M., Yoko-o, T. and Jigami, Y. (2003). "Salt stress induces the expression of the Schizosaccharomyces pombe och1+, which encodes an initiation-specific α-1,6-mannosyltransferase for N-linked outer chain synthesis of cell wall mannoproteins". Biosci. Biotechnol. Biochem. 67: 927–929. PMID 12784644. 
  5. Cui, Z., Horecka, J. and Jigami, Y. (2002). "Cdc4 is involved in the transcriptional control of OCH1, a gene encoding α-1,6-mannosyltransferase in Saccharomyces cerevisiae". Yeast 19: 69–77. PMID 11754484. 
  6. Tsukahara, K., Watanabe, T., Yoko-o, T. and Chigami, Y. (2001). "Schizosaccharomyces pombe och1+ gene encoding α-1,6-mannosyltransferase and use of och1+ gene knockout fission yeast for production of glycoproteins with reduced glycosylation". Jpn. Kokai Tokkyo Koho Koho: 11–11. 
  7. Nakayama, K., Nakanishi-Shindo, Y., Tanaka, A., Haga-Toda, Y. and Jigami, Y. (1997). "Substrate specificity of α-1,6-mannosyltransferase that initiates N-linked mannose outer chain elongation in Saccharomyces cerevisiae". FEBS Lett. 412: 547–550. PMID 9276464. 
  8. Suzuki, A., Shibata, N., Suzuki, M., Saitoh, F., Takata, Y., Oshie, A., Oyamada, H., Kobayashi, H., Suzuki, S. and Okawa, Y. (1996). "Characterization of α-1,6-mannosyltransferase responsible for the synthesis of branched side chains in Candida albicans mannan". Eur. J. Biochem. 240: 37–44. PMID 8797833. 
  9. Yip, C.L., Welch, S.K., Klebl, F., Gilbert, T., Seidel, P., Grant, F., O'Hara, P.J. and MacKay, V.L. (1994). "Cloning and analysis of the Saccharomyces cerevisiae MNN9 and MNN1 genes required for complex glycosylation of secreted proteins". Proc. Natl. Acad. Sci. USA 91: 2723–2727. PMID 8146181. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]