Gingipain R

Izvor: Wikipedia
Gingipain R
Identifikatori
EC broj 3.4.22.37
CAS broj 159745-71-8
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Gingipain R (EC 3.4.22.37, Arg-gingipain, gingipain-1, argingipain, Arg-gingivain-55 proteinaza, Arg-gingivain-70 proteinaza, Arg-gingivain-75 proteinaza, arginin-specifična cisteinska proteaza, arginin-specifična gingipain, arginin-specifični gingivain, RGP-1, RGP) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

Hidroliza proteina i malih molekula, sa preferencijom za Arg u P1

Ovu endopeptidazu izlučuje bakterija Porphyromonas gingivalis.

Reference[uredi - уреди]

  1. Chen, Z., Potempa, J., Polanowski, A., Wikstrom, M. and Travis, J. (1992). "Purification and characterization of a 50-kDa cysteine proteinase (gingipain) from Porphyromonas gingivalis". J. Biol. Chem. 267: 18896–18901. PMID 1527017. 
  2. Kirszbaum, L., Sotiropoulos, C., Jackson, C., Cleal, S., Slakeski, N. and Reynolds, E.C. (1995). "Complete nucleotide sequence of a gene prtR of Porphyromonas gingivalis W50 encoding a 132 kDa protein that contains an arginine-specific thiol endopeptidase domain and a haemagglutinin domain". Biochem. Biophys. Res. Commun. 207: 424–431. PMID 7857299. 
  3. Pavloff, N., Potempa, J., Pike, R.N., Prochazka, V., Kiefer, M.C., Travis, J. and Barr, P.J. (1995). "Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein". J. Biol. Chem. 270: 1007–1010. PMID 7836351. 

Literatura[uredi - уреди]

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