Geranilfarnezil difosfat sintaza

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Geranilfarnezil difosfat sintaza
Identifikatori
EC broj 2.5.1.81
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures

Geranilfarnezil difosfat sintaza (EC 2.5.1.81, FGPP sintaza, (sve-E) geranilfarnezil difosfatna sintaza, GFPS, Fgs) je enzim sa sistematskim imenom geranilgeranil-difosfat:izopentenil-difosfat transtransferaza (dodaje 1 izopentenilnu jedinicu).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju

geranilgeranil difosfat + izopentenil difosfat \rightleftharpoons (2E,6E,10E,14E)-geranilfarnezil difosfat + difosfat

Enzim iz metanosarcina mazei učestvuje u biosintezi poliprenilnog bočnog lanca metanofenazina.

Reference[uredi - уреди]

  1. Ogawa, T., Yoshimura, T. and Hemmi, H. (2010). "Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution". Biochem. Biophys. Res. Commun. 393: 16–20. PMID 20097171. 
  2. Tachibana, A., Yano, Y., Otani, S., Nomura, N., Sako, Y. and Taniguchi, M. (2000). "Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecular evolution with alteration in product specificity". Eur. J. Biochem. 267: 321–328. PMID 10632701. 
  3. Tachibana, A. (1994). "A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis". FEBS Lett. 341: 291–294. PMID 8137956. 
  4. Lee, P.C., Mijts, B.N., Petri, R., Watts, K.T. and Schmidt-Dannert, C. (2004). "Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Eng. Des. Sel. 17: 771–777. PMID 15548566. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]