G-kvadrupleks
U molekularnoj biologiji, G-kvadrupleks (takođe poznat kao G-tetrade ili G4-DNA) je sekvenca nukleinske kiseline koja je bogata u guaninu i ima sposobnost formiranja četvorolančane strukture. Ćetiri guaninske baze se mogu vezati putem Hugstinove vodonične veze da formiraju četvrtastu planarnu strukturu guaninske tetrade, i dve ili više guaninskih tetrada mogu da formiraju stekove, ili G-kvadrupleks. Kvadrupleksna struktura je dalje stabilizovana prisustvom katjona, posebno kalijuma, koji su smešteni u centralnom kanalu između svakog para tetrada.[2] Oni mogu da budu formirani od DNK, RNK, LNA, i PNA, i mogu da budu intramolekularni, bimolekularni, ili tetramolekularni. U zavisnosti od pravca lanaca ili delova lanaca koje formiraju tetrade, strukture se mogu opisati kao paralelne ili antiparalelne.
Reference[uredi | uredi kod]
- ↑ NDB UD0017, Structure and packing of human telomeric DNK
- ↑ Campbell, Nancy H.; Neidle, Stephen (2012). „Chapter 4. G-Quadruplexes and Metal Ions”. u: Astrid Sigel, Helmut Sigel and Roland K. O. Sigel. Interplay between Metal Ions and Nucleic Acids. Metal Ions in Life Sciences. 10. Springer. str. 119-1134. DOI:10.1007/978-94-007-2172-2_4.
Literatura[uredi | uredi kod]
- Johnson JE, Smith JS, Kozak ML, Johnson FB (2008). „In vivo veritas: using yeast to probe the biological functions of G-quadruplexes”. Biochimie 90 (8): 1250–1263. DOI:10.1016/j.biochi.2008.02.013. PMC 2585026. PMID 18331848.
- Huppert JL and Balasubramanian S (2005). „Prevalence of quadruplexes in the human genome”. NAR 33 (9): 2908–2916. DOI:10.1093/nar/gki609. PMC 1140081. PMID 15914667.
- Todd AK, Johnston M, Neidle S (2005). „Highly prevalent putative quadruplex sequence motifs in human DNA”. NAR 33 (9): 2901–2907. DOI:10.1093/nar/gki553. PMC 1140077. PMID 15914666.
- Burge S, Parkinson GN, Hazel P, Todd AK, Neidle S (2006). „Quadruplex DNA: sequence, topology and structure”. NAR 34 (19): 5402–5415. DOI:10.1093/nar/gkl655. PMC 1636468. PMID 17012276.
- Siddiqui-Jain A, Grand CL, Bearss DJ, Hurley LH (2002). „Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription”. PNAS 99 (18): 11593–8. DOI:10.1073/pnas.182256799. PMC 129314. PMID 12195017. Arhivirano iz originala na datum 2007-10-01. Pristupljeno 2014-05-02.
- Rawal P, Kummarasetti VB, Ravindran J, Kumar N, Halder K, Sharma R, Mukerji M, Das SK, Chowdhury S (2006). „Genome-wide prediction of G4 DNA as regulatory motifs: Role in Escherichia coli global regulation”. Genome Res. 16 (5): 644–55. DOI:10.1101/gr.4508806. PMC 1457047. PMID 16651665.
- Xu Hou, Wei Guo, Fan Xia, Fu-Qiang Nie, Hua Dong, Ye Tian, Liping Wen, Lin Wang, Liuxuan Cao, Yang Yang, Jianming Xue, Yanlin Song, Yugang Wang, Dongsheng Liu, and Lei Jiang (2009). „A biomimetic potassium responsive nanochannel: G-quadruplex DNA conformational switching in a synthetic nanopore”. J. Am. Chem. Soc. 131 (22): 7800–7805. DOI:10.1021/ja901574c. PMID 19435350.
- Neidle & Balasubramanian, ur. (2006). Quadruplex Nucleic Acids. ISBN 0-85404-374-8. Arhivirano iz originala na datum 2007-09-30. Pristupljeno 2014-05-02.
- Campbell, Nancy H.; Neidle, Stephen (2012). „Chapter 4. G-Quadruplexes and Metal Ions”. u: Astrid Sigel, Helmut Sigel and Roland K. O. Sigel. Interplay between Metal Ions and Nucleic Acids. Metal Ions in Life Sciences. 10. Springer. str. 119-1134. DOI:10.1007/978-94-007-2172-2_4.
Spoljašnje veze[uredi | uredi kod]
- COST MP0802 kvadrupleksna mreža Arhivirano 2015-06-19 na Wayback Machine-u
- Quadruplex.org Arhivirano 2018-08-13 na Wayback Machine-u