Fotinus-luciferin 4-monooksigenaza (ATP-hidroliza)
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| Fotinus-luciferin 4-monooksigenaza (ATP-hidroliza) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.12.7 | ||||||||
| CAS broj | 61970-00-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fotinus-luciferin 4-monooksigenaza (ATP-hidroliza) (EC 1.13.12.7, luciferaza svitaca, luciferaza (luciferin svitaca), Photinus luciferin 4-monooksigenaza (adenozin trifosfat-hidroliza), luciferaza luciferina svitaca, Photinus pyralis luciferaza) je enzim sa sistematskim imenom Photinus-luciferin:kiseonik 4-oksidoreduktaza (dekarboksilacija, ATP-hidroliza).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Photinus luciferin + O2 + ATP oksidovani Photinus luciferin + CO2 + AMP + difosfat + hnu
Photinus (svitac) je bioluminescentni insekt. Prvi reakcije je reakcije formiranje kiselinskog anhidrida između karboksilne grupe i AMP, uz otpuštanje difosfata. Rad enzima se može pratiti merenjem emisije svetlosti.
Reference[uredi | uredi kod]
- ↑ Hopkins, T.A., Seliger, H.H., White, E.H. and Cass, M.W. (1967). „The chemiluminescence of firefly luciferin. A model for the bioluminescent reaction and identification of the product excited state”. J. Am. Chem. Soc. 89: 7148-7150. PMID 6064360.
- ↑ White, E.H., McCapra, F., Field, G.F. and McElroy, W.D. (1961). „The structure and synthesis of firefly luciferin”. J. Am. Chem. Soc. 83: 2402-2403.
- ↑ White, E.H., Rapaport, E., Hopkins, T.A. and Seliger, H.H. (1969). „Chemi- and bioluminescence of firefly luciferin”. J. Am. Chem. Soc. 91: 2178-2180. PMID 5784183.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.