Fosforibozilaminoimidazolsukcinokarboksamid

Fosforibozilaminoimidazolsukcinokarboksamid
	SAICAR
Naziv po klasifikaciji	2-[(5-Amino-13,4-dihidroksi-5-[(fosfonooksi)metil]oksolan-2-il1H-imidazol-4-il)formamido]butandionska kiselina
Drugi nazivi	2-[(5-Amino-13,4-dihidroksi-5-[(fosfonooksi)metil]oksolan-2-il}imidazol-4-il)formamido]butanedionska kiselina
Identifikacija
CAS registarski broj	3031-95-6 (2S)-2-formamido, (2R,3R,4S5R)-3,4-dihidroksi-5-oksolan-2-ill
PubChem	981, ; 440498 (2R,3R,4S5R)-3,4-dihidroksi-5-oksolan-2-il, ; 160666 (2S)-2-formamido, (2R,3R,4S5R)-3,4-dihidroksi-5-oksolan-2-il, ; 6914598 (2S)-2-formamido, (2R,3S,4S5R)-3,4-dihidroksi-5-oksolan-2-il
ChemSpider	956 , 389419 (2R,3R,4S5R)-3,4-dihidroksi-5-oksolan-2-il , 141175 (2S)-2-formamido, (2R,3R,4S5R)-3,4-dihidroksi-5-oksolan-2-il , 5290480 (2S)-2-formamido, (2R,3S,4S5R)-3,4-dihidroksi-5-oksolan-2-il
KEGG	C04823
MeSH	SAICAR
ChEBI	18319
3DMet	B04963
Jmol-3D slike	Slika 1
SMILES
	NC1=C(N=CN1C1OC(COP(O)(O)=O)C(O)C1O)C(=O)NC(CC(O)=O)C(O)=O
InChI
	InChI=1/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1/f/h16,18,23,25-26H; Kod: NAQGHJTUZRHGAC-ZZZDFHIKBX InChI=1/C13H19N4O12P/c14-10-7(11(22)16-4(13(23)24)1-6(18)19)15-3-17(10)12-9(21)8(20)5(29-12)2-28-30(25,26)27/h3-5,8-9,12,20-21H,1-2,14H2,(H,16,22)(H,18,19)(H,23,24)(H2,25,26,27)/t4-,5+,8+,9+,12+/m0/s1
Svojstva
Molekulska formula	C13H19N4O12P
Molarna masa	454.28 g mol−1
	(šta je ovo?) (verifikuj) ; Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala
	Infobox references

Fosforibozilaminoimidazolsukcinokarboksamid (SAICAR) je intermedijer pri formiranju purina. Konverzija molekula ATP, L-aspartat, i 5-aminoimidazol-4-karboksiribonukleotid (CAIR) u 5-aminoimidazol-4-(N-sukcinilkarboksamid) ribonukleotid, ADP, i fosfat posredstvom enzima fosforibozilaminoimidazolsukcinokarboksamid sintaza (SAICAR sintetaza) predstavlja osmi korak u de novo biosintezi purinskih nukleotida.^[5]

Reference[uredi | uredi kod]

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
↑ Scott W. Nelson, Daniel J. Binkowski, Richard B. Honzatko, and Herbert J. Fromm (2005). „Mechanism of Action of Escherichia coli Phosphoribosylaminoimidazolesuccinocarboxamide Synthetase”. Biochemistry 44: 766–774. DOI:10.1021/bi048191w.

Literatura[uredi | uredi kod]

David L. Nelson, Michael M. Cox (2005). Principles of Biochemistry (4th izd.). New York: W. H. Freeman. ISBN 0-7167-4339-6.
Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0.

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Portal Hemija

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[5] Scott W. Nelson, Daniel J. Binkowski, Richard B. Honzatko, and Herbert J. Fromm (2005). „Mechanism of Action of Escherichia coli Phosphoribosylaminoimidazolesuccinocarboxamide Synthetase”. Biochemistry 44: 766–774. DOI:10.1021/bi048191w.

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Fosforibozilaminoimidazolsukcinokarboksamid

Reference[uredi | uredi kod]

Literatura[uredi | uredi kod]

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