Fosfatidilinozitol-3,4-bisfosfatna 4-fosfataza
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| Fosfatidilinozitol-3,4-bisfosfatna 4-fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.66 | ||||||||
| CAS broj | 123644-80-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fosfatidilinozitol-3,4-bisfosfatna 4-fosfataza (EC 3.1.3.66, inozitol-3,4-bisfosfat 4-fosfataza, D-mio-inozitol-3,4-bisfosfat 4-fosfohidrolaza, fosfoinositide 4-fosfataza, inozitol polifosfat 4-fosfataza, inozitol polifosfat 4-fosfataza tip II) je enzim sa sistematskim imenom 1-fosfatidil-1D-mio-inozitol-3,4-bisfosfat 4-fosfohidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-fosfatidil-mio-inozitol 3,4-bisfosfat + H2O 1-fosfatidil-1D-mio-inozitol 3-fosfat + fosfat
Ovaj enzim ne zavisi od Mg2+ jona.
Reference[uredi | uredi kod]
- ↑ Howell, S., Barnaby, R.J., Rowe, T., Ragan, C.I. and Gee, N.S. (1989). „Evidence for at least four different inositol bisphosphatases in bovine brain”. Eur. J. Biochem. 183: 169-172. PMID 2546770.
- ↑ Norris, F.A., Auethavekiat, V. and Majerus, P.W. (1995). „The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase”. J. Biol. Chem. 270: 16128-16133. PMID 7608176.
- ↑ Norris, F.A., Atkins, R.C. and Majerus, P.W. (1997). „The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family”. J. Biol. Chem. 272: 23859-23864. PMID 9295334.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.