Fosfatidilinozitol-3,4,5-trisfosfatna 5-fosfataza
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| Fosfatidilinozitol-3,4,5-trisfosfatna 5-fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.86 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Fosfatidilinozitol-3,4,5-trisfosfatna 5-fosfataza (EC 3.1.3.86, SHIP1, SHIP2, SHIP, p150Ship) je enzim sa sistematskim imenom 1-fosfatidil-1D-mio-inozitol-3,4,5-trisfosfat 5-fosfohidrolaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1-fosfatidil-1D-mio-inozitol 3,4,5-trisfosfat + H2O 1-fosfatidil-1D-mio-inozitol 3,4-bisfosfat + fosfat
Ovaj enzim hidrolizuje 1-fosfatidil-1D-mio-inozitol 3,4,5-trisfosfat (PtdIns(3,4,5)P3) i formira PtdIns(3,4)P2.
Reference[uredi | uredi kod]
- ↑ Lioubin, M.N., Algate, P.A., Tsai, S., Carlberg, K., Aebersold, A. and Rohrschneider, L.R. (1996). „p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity”. Genes Dev. 10: 1084-1095. PMID 8654924.
- ↑ Damen, J.E., Liu, L., Rosten, P., Humphries, R.K., Jefferson, A.B., Majerus, P.W. and Krystal, G. (1996). „The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase”. Proc. Natl. Acad. Sci. USA 93: 1689-1693. PMID 8643691.
- ↑ Giuriato, S., Payrastre, B., Drayer, A.L., Plantavid, M., Woscholski, R., Parker, P., Erneux, C. and Chap, H. (1997). „Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets”. J. Biol. Chem. 272: 26857-26863. PMID 9341117.
- ↑ Drayer, A.L., Pesesse, X., De Smedt, F., Woscholski, R., Parker, P. and Erneux, C. (1996). „Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase”. Biochem. Biophys. Res. Commun. 225: 243-249. PMID 8769125.
- ↑ Pesesse, X., Moreau, C., Drayer, A.L., Woscholski, R., Parker, P. and Erneux, C. (1998). „The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity”. FEBS Lett. 437: 301-303. PMID 9824312.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.