Fosfatidilholin—sterol O-aciltransferaza
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| Fosfatidilholin—sterol O-aciltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.1.43 | ||||||||
| CAS broj | 9031-14-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Fosfatidilholin—sterol O-aciltransferaza (EC 2.3.1.43, lecitin-holestarolna aciltransferaza, fosfolipid-holestarolna aciltransferaza, LCAT (lecitin-holestarol aciltransferaza), lecitin:holestarol aciltransferaza, lizolecitinska aciltransferaza) je enzim sa sistematskim imenom fosfatidilholin:sterol O-aciltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- fosfatidilholin + sterol 1-acilglicerofosfoholin + sterolni estar
Palmitoil, oleoil i linoleoil ostataci se mogu preneti. Brojni steroli, uključujući holestarol, mogu da deluju kao akceptori. Bakterijski enzim takođe katalizuje reakcije EC 3.1.1.4, fosfolipaze A2, i EC 3.1.1.5, lizofosfolipaze.
Reference[uredi | uredi kod]
- ↑ Bartlett, K., Keat, M.J. and Mercer, E.I. (1974). „Biosynthesis of sterol esters in Phycomyces blakesleeanus”. Phytochemistry 13: 1107-1113.
- ↑ Buckley, J.T., Halasa, L.N. and Macintyre, S. (1982). „Purification and partial characterization of a bacterial phospholipid: cholesterol acyltransferase”. J. Biol. Chem. 257: 3320-3325. PMID 7061477.
- ↑ Glomset, J.A.J. (1968). „The plasma lecithins:cholesterol acyltransferase reaction”. Lipid Res. 9: 155-167. PMID 4868699.
- ↑ Vahouny, G.V. and Tradwell, C.R. (1968). „Enzymatic synthesis and hydrolysis of cholesterol esters”. Methods Biochem. Anal. 16: 219-272. PMID 4877146.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.