Fenobarbital
(Preusmjereno sa stranice Fenobarbiton)
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| (IUPAC) ime | |||
|---|---|---|---|
| 5-etil-5-phenil-1,3-diazinan-2,4,6-trion | |||
| Klinički podaci | |||
| Robne marke | Adonal, Aephenal, Agrypnal, Amylofene | ||
| AHFS/Drugs.com | Monografija | ||
| Identifikatori | |||
| CAS broj | 50-06-6 | ||
| ATC kod | N03AA01 , N03AA02 | ||
| PubChem[1][2] | 4763 | ||
| DrugBank | DB01174 | ||
| ChemSpider[3] | 4599 | ||
| KEGG[4] | C07434 
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| ChEMBL[5] | CHEMBL8069
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| Hemijski podaci | |||
| Formula | C12H12N2O3 | ||
| Mol. masa | 232.2353 | ||
| SMILES | eMolekuli & PubHem | ||
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| Fizički podaci | |||
| Tačka topljenja | 174 °C (345 °F) | ||
| Farmakokinetički podaci | |||
| Poluvreme eliminacije | 53 do 118 sati | ||
| Farmakoinformacioni podaci | |||
| Trudnoća | ? | ||
| Pravni status | |||
| Način primene | Oralno; Intramaskularno; Oralno; | ||
Fenobarbital je derivat barbituratne kiseline, koji deluje kao neselektivni depresant centralnog nervnog sistema. On promoviše vezivanje za inhibitorni tip receptora gama-aminobuterine kiseline, i moduliše protok hlorida kroz receptorske kanale. On snažno inhibira glutamatom indukovane depolarizacije.[6][7][8][9][10][11][12]
Reference[uredi | uredi kod]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.
- ↑ Kwan P, Brodie MJ: Phenobarbital for the treatment of epilepsy in the 21st century: a critical review. Epilepsia. 2004 Sep;45(9):1141-9. PMID 15329080
- ↑ Taylor S, Tudur Smith C, Williamson PR, Marson AG: Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. Cochrane Database Syst Rev. 2001;(4):CD002217. PMID 11687150
- ↑ Tudur Smith C, Marson AG, Williamson PR: Carbamazepine versus phenobarbitone monotherapy for epilepsy. Cochrane Database Syst Rev. 2003;(1):CD001904. PMID 12535420
- ↑ Kalviainen R, Eriksson K, Parviainen I: Refractory generalised convulsive status epilepticus : a guide to treatment. CNS Drugs. 2005;19(9):759-68. PMID 16142991
- ↑ Booth D, Evans DJ: Anticonvulsants for neonates with seizures. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD004218. PMID 15495087
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
