Epimeraza i racemaza
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Epimeraze i racemaze su izomeraze koje katalizuju inverziju stereohemije u biološkim molekulima.[1] Racemaze katalizuju stereohemijsku inverziju asimetričnog atoma ugljenika u supstratu sa samo jednim centrom asimetrije. Epimeraze katalizuju stereohemijsku inverziju konfiguracije asimetričnog ugljenika u supstratu koji ima više od jednog centra simetrije, i stoga interkonvertuju epimere.
Ljudske epimeraze obuhvataju metilmalonil-CoA epimerazu, koja učestvuje u metaboličkom razlaganju aminokiselina izoleucina, metionina i valina, i UDP-glukoza 4-epimeraza, koja se koristi u krajnjem koraku metabolizma galaktoze - katalizuje reverzibilnu konverziju UDP-galaktoze u UDP-glukozu.
Reference[uredi | uredi kod]
- ↑ Tanner, ME. (2002). „Understanding nature's strategies for enzyme-catalyzed racemization and epimerization”. Acc. Chem. Res. 35 (4): 237–246. DOI:10.1021/ar000056y. PMID 11955052.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.