Enoil-KoA hidrataza
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| Enoil-KoA hidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.17 | ||||||||
| CAS broj | 9027-13-8 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Enoil-KoA hidrataza (EC 4.2.1.17, enoilna hidraza, nezasićena acil-KoA hidrataza, beta-hidroksiacil-KoA dehidraza, beta-hidroksikiselinska dehidraza, hidrataza, enoil koenzim A, acil koenzim A hidraza, krotonaza, krotonilna hidraza, 2-oktenoil koenzim A hidraza, enoil koenzim A hidrataza, 2-enoil-KoA hidrataza, kratkolančana enoil-KoA hidrataza, ECH, trans-2-enoil-KoA hidrataza, enoil koenzim A hidraza (D), enoil koenzim A hidraza (L), kratkolančana enoil koenzim A hidrataza, D-3-hidroksiacil-KoA dehidrataza, enol-KoA hidrataza) je enzim sa sistematskim imenom (3S)-3-hidroksiacil-KoA hidrolijaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (3S)-3-hidroksiacil-KoA trans-2(ili 3)-enoil-KoA + H2O
Ovaj enzim deluje u reverznom smeru sa cis-jedinjenjima, dajući (3R)-3-hidroksiacil-KoA.
Reference[uredi | uredi kod]
- ↑ Moskowitz, G.J. and Merrick, J.M. (1969). „Metabolism of poly-β-hydroxybutyrate. II. Enzymatic synthesis of D-(-)-β-hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum”. Biochemistry 8: 2748-2755. PMID 5808333.
- ↑ Stern, J.R. (1957). „Thioltranscrotylase and β-hydroxybutyryl CoA racemase activities of crystalline crotonase”. Biochim. Biophys. Acta 26: 641-643. PMID 13499425.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.