Eksodezoksiribonukleaza I
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| Eksodezoksiribonukleaza I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.11.1 | ||||||||
| CAS broj | 9037-46-1 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Eksodezoksiribonukleaza I (EC 3.1.11.1, Escherichia coli eksonukleaza I, E. coli eksonukleaza I, eksonukleaza I) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Eksonukleolitičko razlaganje u 3'- ka 5'- smeru čime se formiraju nukleozid 5'-fosfati
Ova enzim preferentno deluje na jednolačanu DNK.
Reference[uredi | uredi kod]
- ↑ Blakesley, R.W., Dodgson, J.B., Nes, I.F. and Wells, R.D. (1977). „Duplex regions in single-stranded phiX174 DNA are cleaved by a restriction endonuclease from Haemophilus aegyptius”. J. Biol. Chem. 252: 7300-7306. PMID 71298.
- ↑ Kelley, R.B., Atkinson, M.R., Huberman, J.A. and Kornberg, A. (1969). „Excision of thymine dimers and other mismatched sequences by DNA polymerases of Escherichia coli”. Nature 224: 495-501.
- ↑ Lehman, I.R. and Nussbaum, A.L. (1964). „The deoxyribonucleases of Escherichia coli. V. On the specificity of exonuclease I (phosphodiesterase)”. J. Biol. Chem. 239: 2628-2636. PMID 14235546.
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.