Ekso-a-sijalidaza
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| Ekso-a-sijalidaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.2.1.18 | ||||||||
| CAS broj | 9001-67-6 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ekso-a-sijalidaza (EC 3.2.1.18, neuraminidaza, sijalidaza, alfa-neuraminidaza, acetilneuraminidaza) je enzim sa sistematskim imenom acetilneuraminil hidrolaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- hidroliza alfa-(2->3)-, alfa-(2->6)-, alfa-(2->8)- glikozidnih veza terminalnih ostataka sijalinske kiseline u oligosaharidima, glikoproteinima, glikolipidima, kolominnoj kiselini i sintetičkim supstratima
Ovaj enzim ne deluje na 4-O-acetilisane sijalne kiseline.
Reference[uredi | uredi kod]
Literatura[uredi | uredi kod]
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.