Edotreotid

Izvor: Wikipedia
Edotreotid
DOTATOC.png
Identifikacija
CAS registarski broj 204318-14-9 YesY
PubChem[1][2] 158782
UNII U194AS08HZ YesY
Jmol-3D slike Slika 1
Svojstva
Molekulska formula C65H92N14O18S2
Molarna masa 1421.64 g mol−1



Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje (25 °C, 100 kPa) materijala

Infobox references

Edotreotid je organsko jedinjenje, koje sadrži 65 atoma ugljenika i ima molekulsku masu od 1421,639 Da.

Osobine[uredi - уреди]

Osobina Vrednost
Broj akceptora vodonika 25
Broj donora vodonika 17
Broj rotacionih veza 26
Particioni koeficijent[3] (ALogP) -9,9
Rastvorljivost[4] (logS, log(mol/L)) -8,2
Polarna površina[5] (PSA, Å2) 531,0

Reference[uredi - уреди]

  1. Li Q, Cheng T, Wang Y, Bryant SH (2010). "PubChem as a public resource for drug discovery.". Drug Discov Today 15 (23-24): 1052–7. doi:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). "Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities". Annual Reports in Computational Chemistry 4: 217–241. doi:10.1016/S1574-1400(08)00012-1. 
  3. Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). "Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods". J. Phys. Chem. A 102: 3762–3772. doi:10.1021/jp980230o. 
  4. Tetko IV, Tanchuk VY, Kasheva TN, Villa AE. (2001). "Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Chem Inf. Comput. Sci. 41: 1488–1493. doi:10.1021/ci000392t. PMID 11749573. 
  5. Ertl P., Rohde B., Selzer P. (2000). "Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties". J. Med. Chem. 43: 3714–3717. doi:10.1021/jm000942e. PMID 11020286. 

Literatura[uredi - уреди]

Spoljašnje veze[uredi - уреди]